Sentences with phrase «animal model data»
Drs. Bailey and Powell are gathering their initial animal model data now and aim to publish their results in the next six months.
https://www.sciencedaily.com/ Not exact matches
Prosecuting would be a «difficult and unworkable task, as little or no evidence is available regarding [the substances»] pharmacological activities in vivo in humans and expert witnesses may be reluctant to extrapolate data from animal models, in silico or in vitro studies,» lecturer in criminal law Amber Marks told the committee.
«These data I think [are] the validation, at least in animal models, that this messenger RNA therapy could work.»
«While the data suggests we need to exercise caution when considering the implications of high - fat diets during pregnancy, we can't yet make that leap to apply these findings in animal models directly to humans,» said Dr. Tamashiro.
Researchers performed a meta - analysis of literature examining patients with NASH, and then tested their hypothesis using an animal model, which enabled them to eliminate possible confounders of the clinical data, such as antibiotic exposure and medical comorbidities.
Using data from several sources on 162 terrestrial animals and plants unique (endemic) to the Albertine Rift, the researchers used ecological niche modeling (computer models) to determine the extent of habitat already lost due to agriculture, and to estimate the future loss of habitat as a result of climate change.
They found that, for the same dataset, models that can better describe the data favour sponges at the root of the animal tree, while models that drastically fail to describe the data favour the comb jellies.
She kept feeding the new data into mathematical models that factored in the animals» age, migration patterns and disease prevalence in the population, among other things.
To shed light on the mystery of Bornean elephant's origin, Chikhi and Goossens» team used genetic data analysis and computational modelling to study the past demographic history of these animals.
«Data collected from our study found that pindolol diminishes ethanol intake in animal models of binge - alcohol consumption.
But big data from genetic fingerprinting of animal DNA in a landscape combined with fine - resolution satellite data and sophisticated ecological models can.
While more data are needed to improve the model, and it is unclear if it can be extrapolated to animals of much larger body mass, the researchers hope that it might help predict features of non-avian dinosaur locomotion using data from fossils and footprints.
This may be observed in many natural phenomena: weather, cardiac rhythm, models for population growth, economic data, some chemical reactions, or the voice of humans and animals.
The BUSM researchers believe the data from this study and those reported by others in animal models as well in clinical studies strongly suggest that Avodart may have serious adverse side effects that were not obvious several years ago.
This has led to a demand for people who can understand data collection techniques and analyze vast amounts of data, categorize the data sets, develop models to test hypotheses that can then be used to develop drugs, and test potential candidates in animals.
«The data, at least in animal models, are compelling that the immune system is involved in hypertension,» Coffman says.
«We had previously shown that antiangiogenesis therapies were ineffective in animal models of lymphatic metastasis, but there was no data to explain the mechanism behind those observations,» says Timothy Padera, Ph.D., of the Steele Laboratory of Tumor Biology in the MGH Department of Radiation Oncology, senior author of the paper.
Using a mathematical model that combines a huge number of cattle and badgers that have TB, the researchers were able to quantify the relationship between the two animals and use a big data approach to show that the route of infection for cattle is from other cattle rather than from other species.
«This new animal model is allowing us to generate and gather data that we've never had access to.
Brendan Wintle at the University of Melbourne, Australia, has developed an alternative model that includes data on previous searches in remote regions, as well as aspects of the animal's biology and behaviour.
«You can not really test the idea that animal reservoirs are important other than building a model from the data available.
The researcher reminds us that the study of the modelling, organisation and coordination of the animal behaviour is a clear example of multidisciplinary collaboration: «biologists participate to perform the experiments in the laboratory and provide real data, in coordination with mathematicians and physicists who propose and solve the models.»
New data about habitat temperature and panda distribution, collected across six mountains along the Chinese edge of the Tibetan plateau, confirm what climate models have been suggesting for a while: the animal is struggling to survive as its natural habitat gets hotter.
A team of researchers has validated data and found a new model for paleontologists to use to track the diet of our ancient ancestors and animals by analyzing the wear on their teeth.
Assistant Professor Arindam Basu from NTU's School of Electrical and Electronic Engineering said the research team have tested the chip on data recorded from animal models, which showed that it could decode the brain's signal to the hand and fingers with 95 per cent accuracy.
In animal models joint research activity, PHE will contribute to studies in non-human primates where stored samples from BCG - vaccinated subjects (with a regimen comparable to human immunisation) will be used to generate data which will be comparable to humans.
Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV - related repair characteristics and TTD progeroid phenotypes in animal models.
Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35 - 37] making this an excellent parallel study for our currently reported data.
«It's going to be driven by the data that we obtain» from animal models.
«After the neurobiological studies pointed out the important role of the GABAB receptor in nicotine reward, and we had positive data in a variety of animal models of nicotine dependence, it was time to focus our efforts on discovery of new molecules that could become therapeutics to assist people to quit smoking.»
Once we have all the data from those animal models and from our observational study we can proceed.
Specifically, our data with the CSDS model suggests that animals most susceptible to social stress after going through the 10 - day social defeat paradigm exhibit increased social avoidance behavior, anhedonia and potentiated fear responding to sound cues.
Armed with these models, we will be in a better position to interpret whole - brain activity in more complex animals, such as humans, when technology has sufficiently advanced to collect that data.
The available data suggest that reversal of scopolamine - induced cognitive impairment is a viable model for predicting pharmacodynamic signals of cognition enhancing compounds in animals [91].
Now this latter element, it turns out that we have a real opportunity because as Dave Calkins and others have now demonstrated very beautifully in animal models, and we even have very good data now in humans; in glaucoma there's an injury that happens first, and it's the death or loss of the cell that happens later in the disease.
The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.
Other data with either gene - deficient animals or with agonist reagents to 4 - 1BB have highlighted another aspect of biology in that a suppressive activity has been observed, for example, where stimulating 4 - 1BB in autoimmune models of MS or rheumatoid arthritis inhibits disease progression and pathology.
Each uses a different approach to targeting these malformed proteins, and is supported by data in animal models — and the early human evidence looks favorable, if very preliminary.
Having previously published data on a variety of experimental mAbs against AS species in animal models -LRB-[16,20]; possibly [21]-RRB-, Prothena's Dale Schenk presented new data on additional experimental antibodies at SENS Research Foundation's Rejuvenation Biotechnology 2014 conference, roughly contemporaneous to its publication, [22] along with information specific to the humanized candidate PRX002, which is now being advanced into clinical trials.
To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.
Only one animal's full connectome has been constructed thus far: the roundworm C. elegans, which has a mere 302 neurons and serves as the model for research and data sharing in the field.
We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age - related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations.
These data should be informative for the development of future animal models of Parkinson's disease.
Utilizing data collected from human clinical populations, Dr. Ressler and his team identify genetic traits and neural processes that may contribute to the underlying causes of these illnesses and provide novel targets for animal models research.
These data suggest that amylin acts on the pathological cascade in animal models of AD, and further supports the therapeutic potential of amylin - type peptides for AD.
Research Diets, Inc is the leading manufacturer of custom, purified OpenSource diets and scientific instrumentation for Biological Data Acquisition in laboratory animal models worldwide.
His research group actively collaborates with several pharmaceutical companies to provide valuable preclinical data in animal models for their targeted drugs.
Berman faculty have led or served on committees of the National Academy of medicine related to human and to animal research and led work for the National Cancer Institute creating model national guidance on informed consent; Berman faculty have served on multiple Data Safety and Monitoring Boards for federally and privately funded trials including the recent NIH sponsored ebola trials.
The animal data is not as strong as human data (animals are imperfect models for humans), but it certainly gives an indication of what might be expected in people.
Recent data from animal models suggest that consumption of BCAA's between meals can overcome the refractory response in protein synthesis that occurs when plasma amino acids are elevated, yet protein synthesis is reduced [174].