Sentences with phrase «animal model developed»

The overall objective of PlacID is to validate the non-human primate animal model developed at NIAID - LMIV for the evaluation of the placental malaria vaccine candidates and to assess it as a platform for testing placental malaria vaccine candidates prior to human testing.

Not exact matches

-LCB- Project -RCB- COWCALF: Developing robust and economically viable models for cow - calf suckling in organic dairy systems, fulfilling high standards for animal health, welfare and ethics.

Researchers examine correlations to develop testable hypotheses that can be examined in non-human animal models.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Researchers at the University of Missouri developed a new molecule in April 2014 that was found to be highly effective in animal models exhibiting SMA.

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

In medicine today, physician - scientists and basic scientists supplement support for their research by applying their expertise part time to develop and test commercial products.1 In my own field, vision science, university - based researchers obtain additional funding through clinical and electrophysiologic studies, pathology, imaging, biochemistry, and animal model development performed for pharmaceutical and instrument companies.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

Nath's team is currently developing an animal model of Nodding syndrome to further study the disease and test potential therapies.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

Weaver studied the animal models for as long as 100 days, and found that the islet clusters transplanted with the hydrogel and VEGF developed many blood vessels and engrafted into their new locations.

The study took advantage of an important large animal model of SMA, the SMA piglet developed by the research group.

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease.

McDonald is working with medicinal chemists at Vanderbilt to develop more selective and potent PGD inhibitors for testing in animal models, with the ultimate goal of moving these inhibitors into clinical trials for pancreatic cancer patients.

«Right now, we have this whole pipeline where drugs are developed, and animal toxicology models are a very important part of that,» she says.

In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α - synuclein.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

He cautions there is a huge gap between the simple response of single - celled animals and the cognitive abilities of developed species, but adds there is no doubt that a combined set of simple circuit models will have more complex behaviour.

Hope Mirendil, an alumna of the TSRI graduate program and first author of the new study, spearheaded the effort to develop the first - ever animal model of fetal cerebral hemorrhage.

The researchers hope these findings will aid in developing new treatments by using animal models that more closely represent the types of mutations apparent in the vast majority of patients with enchrondromas.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

One intriguing development is a potential animal model for smallpox developed by virologist Peter Jahrling of the U.S. Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland, and his colleagues.

Moving to an animal model, they applied the nanoparticles and hydrogen peroxide topically to the teeth of rats, which can develop tooth decay when infected with S. mutans just as humans do.

The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»

The abscesses contained Gram - negative bacteria, and when similar bacterial infections were deliberately induced in the CCM model animals, about half of them developed significant CCMs.

«This is something the hepatitis C field is in dire need of,» says Stanley Lemon of the University of North Carolina in Chapel Hill, as it is very difficult to develop a vaccine without an animal model.

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

The next step would be to develop an animal model, Zakharchenko said.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

Powers is planning expand his study size and is partnering with another CCTS - funded stroke investigator who developed an animal model of ischemia in order to analyze micro-RNA released in brain tissues at the precise area around a blocked blood vessel.

In past studies to develop a new animal model for the brain events that support motor development, neurophysiologist Martin Garwicz of Lund University in Sweden and his colleagues discovered that the schedules by which ferrets and rats acquire various motor skills, such as crawling and walking, are strikingly similar to each other; the progress simply happens faster for rats.

«Usually, when researchers want a mouse or other animal model to express fluorescent proteins in certain cells, they need to develop genetically modified animals that can take months to years to make and characterize,» says former graduate student and first author Ken Chan (PhD» 17).

Scientists have developed the first true animal model of Huntington's disease, a progressive and often fatal deterioration of the central nervous system.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies requires animal models of disease that closely replicate the human condition.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

However, animal results are a critical measure of the validity of the computer models being developed.

MERS and SARS: The pause includes three grants and two contracts that are attempting to develop a strain of the MERS coronavirus that sickens mice so that researchers will have an animal model for testing MERS drugs and vaccines.

Kanta Subbarao of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, said her group has had to stop its efforts to adapt the MERS virus to mice to develop an animal model for the disease.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.

This has led to a demand for people who can understand data collection techniques and analyze vast amounts of data, categorize the data sets, develop models to test hypotheses that can then be used to develop drugs, and test potential candidates in animals.

Long - awaited breakthroughs in developing preclinical animal models are signaling a new era for liver - targeted viruses and beyond

That's because they may have finally developed a tissue model for the human heart that can bridge the gap between animal models and human patients.

The U.S. government has lifted a temporary ban on research attempting to develop an animal model for the MERS (Middle East respiratory syndrome) virus, a deadly coronavirus spreading from camels to people in the Middle East.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

University of Adelaide researchers in Australia, supported by the Invasive Animals Co-operative Research Centre, have developed a model of the likelihood of establishment of alien species of snakes and other reptiles if they are introduced to the wild, accidentally or on purpose.

To tackle their simulation, the pair turned to computer models originally developed by ecologists to predict an animal's geographic range.

Brendan Wintle at the University of Melbourne, Australia, has developed an alternative model that includes data on previous searches in remote regions, as well as aspects of the animal's biology and behaviour.