Sentences with phrase «animal model studies with»

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

Not exact matches

«By studying how education changes the brain, we can find out how this uniquely human experience induces change in both brain structure and function — something we can not do with animal models.»

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Senior author Byungkook Lim, an assistant professor in the Neurobiology Section, said the results require much more study and evaluation to be applied to humans with depression, but the new research in animal models provides solid grounding.

To find out what impact this might have on a flu epidemic, Earn and his colleagues turned to a 1982 study which showed that ferrets, a common animal model for human flu, produced more seasonal flu virus if their fevers were lowered either with painkillers or by having their fur shaved off.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

Weaver studied the animal models for as long as 100 days, and found that the islet clusters transplanted with the hydrogel and VEGF developed many blood vessels and engrafted into their new locations.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

«Despite the prevalence of abnormal sleep patterns in PD, very few studies to date have outlined sleep disturbances in animal models of PD,» says Sarah M. Rothman, PhD, a researcher with the National Institute on Aging, in Baltimore, MD..

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

The potential strategy — which targets metabolic pathways that are active only during intestinal inflammation — prevented or reduced inflammation in a mouse model of colitis while exerting no obvious effect in control animals with healthy, balanced bacterial populations, said Dr. Sebastian Winter, Assistant Professor of Microbiology and co-corresponding author of the study published online today in Nature.

«Then we can do hypothesis - driven studies of this trait with animal or cellular models.»

A fourth study, led by Misty D. Smith, Ph.D. at the University of Utah (abstract 1.215), explores how CBD interacts with five different AEDs in animal models of seizure.

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

A fourth study highlights possible interactions of CBD with existing anti-epileptic drugs (AEDs) in animal models of seizures.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

«This is the first animal model to link pathological shifts in endogenous bacteria with the inhibition of regeneration,» says Alejandro Sánchez Alvarado, Ph.D., an investigator at the Stowers Institute and the Howard Hughes Medical Institute, and senior author of the study.

With distance identified as a key factor, the ideal animal model to study this disease, Dorn quipped, is the giraffe.

Ko is quick to note that these new findings do not warrant radical dietary changes in people with Crohn's: More studies, including more refined genetic analyses of fatty acids and Crohn's and testing in animal models, are needed.

Powers is planning expand his study size and is partnering with another CCTS - funded stroke investigator who developed an animal model of ischemia in order to analyze micro-RNA released in brain tissues at the precise area around a blocked blood vessel.

Yong, a neuroscientist, initially had the idea to test the acne medicine in an animal model since minocycline has many anti-inflammatory properties that he thought could be useful in treating MS. Soon after obtaining successful research results, in studies also supported by the MS Society of Canada and MSSRF, Yong teamed up with Metz who led the transition into a pilot clinical trial, then a Phase 2, and finally the definitive Phase 3 trial.

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

In order to answer the question if animals are capable of mental time travel, the researchers relied on published experimental studies and matched the results with their model.

Dr. Zhu said he believes the study provides the scientific community with an important animal model to further investigate ARID1B's role in human brain disorders and will be a useful tool for therapeutic testing of potential treatments for autism, intellectual disability, and Coffin - Siris syndrome.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

Many diseases can be detected at the surface of tissues, including cancer, while many pre-clinical studies are performed with animal models and engineered three - dimensional tissues that can benefit from being monitored non-destructively.

This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»

In addition to the animal model, the scientists also studied 33 patients with neurodermatitis and found that they have increased quantities of MDSCs in their blood and on their skin in comparison to healthy individuals.

«We need to follow up with functional studies, such as in animal models or at least in vitro systems, to pinpoint and validate the biological basis for selection.»

Future studies should investigate whether, or how, the genetic alterations that lead to this ASD animal model change the serotonin system, with the aim to provide possible insight into serotonergic deficits in human patients, the authors say.

And a variety of studies with animal models has shown that nanoparticles can trigger damage in living tissues (Science, 18 June 2004, p. 1732).

The researcher reminds us that the study of the modelling, organisation and coordination of the animal behaviour is a clear example of multidisciplinary collaboration: «biologists participate to perform the experiments in the laboratory and provide real data, in coordination with mathematicians and physicists who propose and solve the models.»

«By using an animal model to expand tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.

The initial results of the cow study, showing that people do empathize with the animal, indicate that the same model could be useful in other experiments, he said.

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves» disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

In studies to determine the efficacy of the microspheres, Clyburn and his team contaminated two metal implants with staphylococcus aureus bacteria and coated one in the microspheres before inserting them in animal models.

In animal models joint research activity, PHE will contribute to studies in non-human primates where stored samples from BCG - vaccinated subjects (with a regimen comparable to human immunisation) will be used to generate data which will be comparable to humans.

My interest and expertise in immunotherapy started in early 1990s with animal models of IL - 2 and IL - 15 cytokines and natural killer cell development, continued with high dose IL - 2 studies and subsequently Phase I - III trials with both CTLA - 4 and PD1 / PDL -1 checkpoint inhibitors.

Taking advantage of fly genetics The research will combine the strength of the fly system (animals that are short lived but complex enough to model regenerative activity in vertebrates) with genetic studies in mice to understand the role of mTOR signaling in maintaining the health of adult stem cells in both species.

The current series of studies present findings from two animal models of PTSD, namely the mouse chronic social defeat (CSDS) model (Berton et al., 2006; Golden et al., 2011) recently developed in collaboration with Dr. Eric Nestler and also the fear - conditioned, Wistar - Kyoto (WKY) rat model (DaSilva et al., 2011; 2013).

Scientists need other animal models as well, and major breakthroughs have been made and are in the process of being made thanks to studies conducted with these animals:

Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

«The level of Lactobacilllus phage phiadh correlated with the prevalence of immunological disorders... which has been shown in animal models to alter the microbiome,» the Johns Hopkins study said.

Abstract: Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

«We discovered that a specific protein, thrombospondin - 2 (TSP2), is elevated in wounds of patients with diabetes as well as in animal models of diabetes,» said Britta Kunkemoeller, a doctoral student at Yale University who conducted the study.