Sentences with phrase «animal model system»
The disease progressed very gradually, just as it does in humans, suggesting that the hamsters could provide a useful animal model system.
http://discovermagazine.com/
In many animal model systems, for example, the precise genes involved in sexual partner selection have been identified, and their neuro - biochemical pathways have been worked out in great detail.
Finally, a number of other studies of vaccines in animal model systems have been reported but presence or absence of immunopathology after challenge was not reported.
Not exact matches
-LCB- Project -RCB- COWCALF: Developing robust and economically viable models for cow - calf suckling in organic dairy systems, fulfilling high standards for animal health, welfare and ethics.
To evaluate a model system of inspection, operating under HACCP principles, a third inspection system known as HACCP - based Inspection Models Project (HIMP) was initiated in 1998 to evaluate the ability of the HIMP model to improve the safety of processed animals and poultry.
The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.
«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.
«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»
From here, we'll be optimizing the delivery system, evaluating the approach in more severe models of DMD, and assessing efficiency and safety in larger animals with the eventual goal of getting into clinical trials.»
These tools, coupled with animal models of disease and with the latest methodologies in genomics and proteomics, are leading to vast amounts of information about the nervous system under normal and pathologic conditions.
A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals» growth and leading to significant economic losses.
In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.
He also wants to test his system in vivo in animal models.
Using the freshwater polyp Hydra as a model organism, the Kiel - based researchers and their international colleagues investigated how the simple nervous system of these animals interacts with the microbiome.
«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.
Using electrophysiology and pharmacological tools, the research has shown that a potassium channel, specifically the BK channel, in the central nervous system can be regulated with drugs to increase or decrease these disruptions in animal models.
The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.
«This is particularly significant because drugs that work on the serotonin system are the mainstay treatment for OCD in humans, which demonstrates further correlation between the human and animal models,» says Dodman.
The end goal is to create a system that can be used to test drugs that is more accurate and reliable than animal models.
In the next five to 10 years, we'll eliminate much of animal toxicology and move on to smarter systems using computer algorithms and modeling,» he says.
The effectiveness of the platelet - like particles has been tested in an animal model and in a microfluidic chamber designed to simulate conditions within the body's circulatory system.
In all three animal models, the researchers utilized a recombinant adeno - associated viral (rAAV) vector delivery system based on a subtype known as AAV - DJ / 8.
The TNP lab previously demonstrated in animal models that tau is a critical part of the «garbage disposal system,» in cells allowing them to clear accumulated toxic proteins.
«Nanoparticles combine photodynamic and molecular therapies against pancreatic cancer: Novel drug - delivery system cuts off common treatment escape pathways in animal models.»
Scientists have developed the first true animal model of Huntington's disease, a progressive and often fatal deterioration of the central nervous system.
Testing in an animal model revealed that the electrically generated NO produced by both systems was as effective as tank - delivered gas in relieving pulmonary hypertension.
As next steps, the researchers would like to test their hydrogel matrix in animals with normal immune systems and in disease models.
The researchers used proteins from baker's yeast — a model organism for the more complex systems found in animals.
Daniel Villarreal, a graduate student in the Weiner lab, and colleagues report in Cancer Research this week that the protein IL - 33 boosts the immune system of a human papilloma virus animal model of cancer.
We also want to use this system to explore which substances could counteract the progress of neurodegeneration in the brain without having to use animal models at this early stage.
The system has currently been tested in an animal model.
«Importantly, we use mice as models of human beings in research, and so when looking for anti-obesity drugs, we need to fully understand the function of the NPY system in this animal model to understand how similar circuits in humans connect with the body clock.»
«The team will further evaluate the long - term biocompatibility of the modified insulin system in an animal model before determining whether to move to clinical trials,» says co-author Dr. John Buse, professor of medicine at the UNC School of Medicine and director of the UNC Diabetes Care Center and the NC Translational and Clinical Sciences Institute.
«The data, at least in animal models, are compelling that the immune system is involved in hypertension,» Coffman says.
By using fruit fly as a model system, Minna Poukkula working at the Institute of Biotechnology, University of Helsinki, has found out how actin - rich protrusions contribute to cell migration in animal tissues.
The research team is now starting to test the robotic system in a large animal model of short bowel syndrome.
It is also the first to demonstrate that a deep convolutional neural network — a computing system modelled after the neuron activity in animal brains that can basically learn on its own — can effectively differentiate between similar plants with an amazing accuracy of nearly 100 %.
After testing the system both in vitro and in vivo in an animal model, Scott's team demonstrated they could administer a subcutaneous injection that slowly delivered nanomaterials to cells in lymph nodes for over a month in a controlled fashion.
Scientists at Technische Universität München (TUM) and the University of Tübingen have now shown in an animal model that these infections can severely disrupt the immune system, thus aggravating the skin condition.
«We need to follow up with functional studies, such as in animal models or at least in vitro systems, to pinpoint and validate the biological basis for selection.»
«With this novel animal model, we showed how it enhances fear rather than reducing it and where the molecular changes are occurring in our central nervous system.»
Information and Intelligent Systems: Advancing Human - Centered Computing, Information Integration and Informatics, and Robust Intelligence The concept of robust intelligence «encompasses computational understanding and modeling of the many human and animal capabilities that demonstrate intelligence and adaptability in unstructured and uncertain environments.»
Future studies should investigate whether, or how, the genetic alterations that lead to this ASD animal model change the serotonin system, with the aim to provide possible insight into serotonergic deficits in human patients, the authors say.
TOKYO — One of science's favorite lab animals, the mouse, is about to become an even more useful model system.
The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.
UNISI is WP Leader of WP13 TNA7 «Immunocorrelates and Systems Biology»; and partner of WP5 JRA4 «Immuno - correlates and Systems Biology», WP3 JRA1: Improved optimisation and harmonisation of cross-vector screening, WP7, TNA 1 «Cross-platform screening and optimisation service» and WP6 «JRA5: Animal models»
Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases
High quality technical services across four different service platforms are offered: Technology (for process development and GMP production), Immunocorrelates & Systems Biology, Animal models, and support for Clinical Trials.
Swine and lamb model for immunisation of neonates (IRTA, SWR): The development of immunity after the vaccination of human and animal neonates is hampered by the presence of maternal antibodies and an underdeveloped / uneducated immune system.
It's been used to study automobile cruise control systems and population growth of certain animal species, and now researchers think Markov modeling could one day help a woman and her physician...