Sentences with phrase «animal models at»

We are very happy with this fruitful collaboration and we totally recommend genOway for developing animal models at any stage.»

The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and even subcellular structures.

Kohn and his former student Cecile Beguin selected four of these compounds and synthesized them along with five other analogs to evaluate in animal models at the National Institutes of Health (NIH).

The faster speed means it will be possible for the first time to watch disease progression in living animal models at the molecular level.

We also want to use this system to explore which substances could counteract the progress of neurodegeneration in the brain without having to use animal models at this early stage.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

However, a new study conducted in an animal model at Wake Forest Baptist Medical Center showed that fructose rapidly caused liver damage even without weight gain.

Not exact matches

The Volvo S90 2017 model banners its «moose detector,» a trio of radar, camera and software aimed at identifying large animals on the road and avoiding situations such as car - deer collisions.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

Because this exersaucer has a three - position height adjustment, though, it is likely that at some point you'll see your baby happily jumping up and down while looking in the mirror, shaking the rattle or gripping the stuffed animal that's connected to, and detachable from, this model.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

«Hi Tor operates as a no - kill shelter and we are here to help all animals survive and thrive, however we must be able to operate on a fiscally sound business model or risk insolvency and the possibility of putting these animals lives at risk.

Initial studies conducted by Christine Radtke, new Professor for Plastic and Reconstructive Surgery at MedUni Vienna / Vienna General Hospital, have shown in an animal model that the threads have great potential for nerve and tissue repair.

New research from an international group led by Min Zhao, professor of ophthalmology and of dermatology at the University of California, Davis, shows that, in animal models of diabetes, slow healing is associated with weaker electrical currents in wounds.

Researchers at the University of Missouri developed a new molecule in April 2014 that was found to be highly effective in animal models exhibiting SMA.

In a paper published in the journal Systematic Biology and delivered at the Society for Molecular Biology and Evolution Conference this week, Dr Phillips said biases in models of DNA evolution inflated estimates of when modern mammals, which were once no larger than a guinea pig, diversified and evolved into the animals familiar to us today.

The findings are interesting, says René Hen, a neuroscientist who studies depression at Columbia University in New York, but «animal models of depression are very imperfect.»

«These data I think [are] the validation, at least in animal models, that this messenger RNA therapy could work.»

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

There are many promising drugs under development at life sciences companies that have just been waiting for a usable animal model.

«Before our work in rhesus monkeys, it has not been possible to detect or observe some of these symptoms in other HD animal models, especially emotional dysregulation,» says senior author Chan, associate professor of human genetics at Yerkes National Primate Research Center and Emory University School of Medicine.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

Next, Ubogu and his team looked at an animal model of AIDP where they were able to block CD11b early in the disease process.

Using a new technique to deliver gene - therapy - like intervention directly where it's needed, researchers at Thomas Jefferson University successfully increased or decreased the muscle tone of the anal sphincter in appropriate animal models.

But the models also indicated that the birds» coordination would have to be exceptionally precise to make a difference, and many scientists had doubted that the animals could achieve such a feat during flight, says ecophysiologist Steven Portugal at the Royal Veterinary College in Hatfield, UK.

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease.

Neurologist Malcolm MacLeod of the Centre for Clinical Brain Sciences at the University of Edinburgh and his colleagues combed through papers reporting the efficacy of drugs in eight animal disease models and checked whether the authors reported four measures that are widely acknowledged to reduce the risk of bias.

McDonald is working with medicinal chemists at Vanderbilt to develop more selective and potent PGD inhibitors for testing in animal models, with the ultimate goal of moving these inhibitors into clinical trials for pancreatic cancer patients.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

Dr. Michael M. Yartsev, Research Associate and C.V. Starr Fellow at the Princeton Neuroscience Institute at Princeton University receives the US$ 25,000 research prize for his work using the bat as an unusual animal model to study the underlying neural mechanisms of spatial memory and navigation in the mammalian brain.

They found that, for the same dataset, models that can better describe the data favour sponges at the root of the animal tree, while models that drastically fail to describe the data favour the comb jellies.

And at Boston College, biochemist David Newburg and his colleagues have found that another oligosaccharide called 2» - fucosyllactose is effective at warding off Campylobacter, cholera, and enteropathogenic E. coli — a frequent cause of diarrhea — in animal models.

Still, he says, other groups have arrived at opposing results regarding the role of T cells in the disease, in part, perhaps, because their animal models aren't the same.

A fourth study, led by Misty D. Smith, Ph.D. at the University of Utah (abstract 1.215), explores how CBD interacts with five different AEDs in animal models of seizure.

In the animal model, so - called DNA crosslinkers have shown to be very efficient at this.

In animal models or petri dishes, scientists disable one gene at a time to see how it affects the proposed network.

«The big question about why we mammals affiliate with one potential partner versus another finally has a handle we can use in a small animal model,» says Lucy Brown at the Albert Einstein College of Medicine in New York.

Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia - like behaviors, brain changes and global gene expression in an animal model.

Why the drug combination works in resistant CML Why such a combination of the two inhibitor types works in an animal model has now been explained by Prof. Stephan Grzesiek's team at the Biozentrum of the University of Basel and Dr. Wolfgang Jahnke from Novartis, by a structural analysis using nuclear magnetic resonance spectroscopy (NMR).

Most are already being tinkered with in animal models, and at least four have reached clinical trials in humans.

«We have demonstrated for the first time in an animal model that maternal use of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, resulted in increased fat accumulation and inflammation in the liver of the adult offspring, raising new concerns about the long - term metabolic complications in children born to women who take SSRI antidepressants during pregnancy,» says PhD student Nicole De Long, who presented this research on June 22nd at the joint meeting of the International Society of Endocrinology and The Endocrine Society.

The researchers, who evaluated the BSCB in test animals at seven and 30 days after stroke modeling, found that ischemic stroke damaged the gray and white matter in the cervical spinal cord on both sides of the spinal column, based on analysis of electron microscope images.

«This is the first animal model to link pathological shifts in endogenous bacteria with the inhibition of regeneration,» says Alejandro Sánchez Alvarado, Ph.D., an investigator at the Stowers Institute and the Howard Hughes Medical Institute, and senior author of the study.

In five other studies published over the past year, Taffe, Dickerson and their laboratories have looked at the effects of MDPV and a related «bath salts» cathinone derivative, mephedrone, in a range of animal models.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

With this in mind, he and Amit Kapoor, also at Columbia, set out to find a smaller animal that could serve as a model for hepatitis C.

Some of them began looking at animal models, but progress has been slow; the concept of a ghrelin «vaccine» has been floated, but clinical trials are still years off.