Sentences with phrase «animal models do»

Because of the pivotal role that diet plays in causing the MS in humans, most metabolic disease animal models do (and we believe should) use diet as a way to precipitate this syndrome.

Because each patient has a different pattern of disease onset and duration, this model may replicate Huntington's more faithfully than animal models do.

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

Yet systematic reviews tell us conclusively that animal models do not translate well to human mental health.

Findings made in animal models do not always translate to patients, but it appears that this important eye vessel functions very similarly in mice and humans.

Earlier studies involving animal models did not translate to humans.

«Right now, one of the biggest areas of failure is in phase II trials, when you get to those places where you're looking for efficacy and you suddenly discover that the compound that worked great in your animal model doesn't do much in humans,» he says.

Earlier studies involving animal models did not translate to humans.

Not exact matches

How closely does this model correspond to the structure of an animal body?

What sorts of mental lives do animals have, and how should we understand welfare?By presenting models for understanding animals» moral status and rights, and examining their mental lives and welfare, David DeGrazia explores the implications for how we should treat animals in connection wi...

«What I've tried to do is create a sustainable organic farming model that is good for the earth, the soil, the animals, and the people working on these farms, and helps revitalize rural communities,» said Albert Straus, CEO and founder of Straus Family Creamery.

Most of the studies that have produced the craze over PRP have been done using animal models.

«By studying how education changes the brain, we can find out how this uniquely human experience induces change in both brain structure and function — something we can not do with animal models.»

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

«What we had done for the cystic fibrosis pigs was applicable to other diseases» for which the previous animal models were not sufficient, Rogers says.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

In animal models, acupuncture appears to impact the same biologic pathways ramped up by pain and stress, analogous to what drugs do in humans.

While scientists could do cellular work in animal models on the role of dopamine versus glutamate, and they could do EEGs in human beings, a bridge between the two remained elusive.

They were able to do so by building on an experiment showing that grafting a peripheral nerve into the space between a severed spinal cord in an animal model brought about nerve regeneration (albeit limited).

It's extremely important to choose the appropriate animal models, and veterinarians have the training to do that.»

He took his prior work and expertise in the area of gastrointestinal motility and applied it to a new animal model, the zebra fish, to show that he could do what he proposed to do and then added a new hook to get it funded.

Harding also argues that because rodent studies suggest that these animals do lose neurons to alcohol, they may be unreliable models for the human hippocampus.

The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.

Ojima says, «Once we have drug candidates that are ready to go into animal models, preclinical studies, toxicology, and such things, it really takes companies to do that.»

«Then we can do hypothesis - driven studies of this trait with animal or cellular models.»

Granular resistive force theory, which considers the thrust provided by the body waves and the drag on the animals» bodies, helped model the locomotion and compare the energy efficiency of the limbless snake against that of the four - legged lizard — which doesn't use its legs to swim through the sand.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

He had no animal model of the infection to use in his studies — rats and mice are not susceptible — so he famously used an experimental subject that did not require ethics approval or special funding: himself.

Moving to an animal model, they applied the nanoparticles and hydrogen peroxide topically to the teeth of rats, which can develop tooth decay when infected with S. mutans just as humans do.

Studies of IBD are typically performed using cell culture experiments or animal models, which don't mimic the precise conditions that occur in the gut of human patients.

Ko is quick to note that these new findings do not warrant radical dietary changes in people with Crohn's: More studies, including more refined genetic analyses of fatty acids and Crohn's and testing in animal models, are needed.

A lot of the work that we do relies on the use of rodents, animal models, rats and mice in particular.

«Some unexpected phenotypes in animal models can actually lead to something very important in cancer biology that we didn't expect.

The novel biologic has been tested in cell and animal models, and the results are that the cancer does not grow as aggressively and responds to chemotherapy.

Early treatments in animal models in vivo with hotter lasers didn't work as well.

The disease progressed very gradually, just as it does in humans, suggesting that the hamsters could provide a useful animal model system.

«I did a lot of modelling to work out how far we needed to move the mine before detonating it — for the protection of both the pipeline and the animals that we know live in that area.»

Even though it doesn't have a head, you can still tell what kind of animal it is: the robot is definitely modeled upon a cat.

The research, done in an animal model, was supported by the National Institutes of Health, the Crohn's and Colitis Foundation, and the Regenerative Engineering and Medicine Center operated by Emory University, Georgia Tech and the University of Georgia.

«When you use animal models and do the things that are commonly done in assisted reproduction, the answer is yes — it affects DNA methylation.»

It's not clear what would happen to the rest of NCRR's portfolio, which includes support for construction and instrumentation, primate centers and other model animal resources, and grants for minority institutions and states that don't have much NIH funding.

Specifically, the IOM committee says NIH should support only biomedical research with chimpanzees if it promises to advance public health, can not be done with another research model or ethically performed with humans, and the animals are kept in ecologically appropriate housing or habitats.

After an ischemic stroke in the middle cerebral artery — one of the most common types of stroke in humans — the animal models showed much lower overall fluid intake but increased preference for alcohol over water when they did drink.

The recommendations are all the more critical given that the models don't take into account other threats to lemurs and the many animals that share their forest home, the researchers say.

They said my grant proposal was too preliminary, not focused, too ambitious, just a descriptive survey, a large fishing expedition, did not have an adequate animal model, did not provide a clear rationale, and was viewed with a low level of enthusiasm.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

The model shows that if animals are still doing what they did before habitat damage caused by decades of agricultural intensification, then large, early - nesting species such as great tits will be fine, but late - nesting species such as tree sparrows will decline.

Though the scientists don't know if such individual and pack behavior is a common occurrence, observations like these on Isle Royale provide insight into how animal societies function as well as the vicissitudes of the food chain cycle on Isle Royale, also helping to inform other models of the natural world.

Because M. lepromatosis can not be grown in the lab and animal models for this version of leprosy do not exist yet, the scientists used an infected skin sample from a patient in Mexico to obtain the bacterium's genetic material.