Sentences with phrase «animal models for human disease»

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

FOA encourages research grant applications from institutions / organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Not exact matches

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal model to study the neurological basis for Huntington's disease.

One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies requires animal models of disease that closely replicate the human condition.

The investigators used the nanoparticle plus the iRGD to deliver irinotecan in a robust animal model for pancreatic cancer that closely mimics human disease.

Critics charge that rabbits are not good animal models for human brain diseases and note that the dialysis patients suffered from dialysis encephalopathy, or «dialysis dementia,» not Alzheimer's disease.

«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.

This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.

One challenge has been the lack of animal and cellular models that can precisely replicate the human disease for scientific investigation.

This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35 - 37] making this an excellent parallel study for our currently reported data.

His major research interests are human neuroanatomy and neuropathology and the use of animal models to test novel therapies for neurodegenerative diseases including Alzheimer's disease.

«During the next 10 years,» says Svendsen, «we're going to see a trend away from using animals for disease modeling and using human cells with iPS technology instead.»

Animals provide a useful model for diseases found in both humans and other aAnimals provide a useful model for diseases found in both humans and other animalsanimals.

His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.

Each cell - based treatment approach is presented as a potential therapy for a specific disease or a disease category (e.g.: cardiovascular diseases, metabolic diseases, etc.), studied in animal models or in humans.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

«Using an animal model that's relevant to human disease, Fouchier and Kawaoka have shown that relatively few mutations may be required for an influenza virus to evolve into astrain that can pass effectively between individuals and cause serious illness.

She is also exploring their role in animal models for human conditions including Huntington's disease, Parkinson's disease, and drug addiction.

This result has implications for interpreting disease phenotypes in animal models and humans.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.

An important step in developing effective treatments for human disease is finding an effective animal model of the disease to test potential therapies.

In the study, lead author Duncan Lascelles, CVM professor of small animal surgery and pain management, outlines an comprehensive argument for the translational power of utilizing companion animals with naturally occurring diseases as models of human conditions.

Recently, the section has been involved in collaborative work investigating farm animal conditions as models for human diseases.

These mutations establish CMR as a novel animal model for Best macular dystrophy (BMD) in humans, an autosomal dominant, childhood retinal disease also caused by mutations in the Bestrophin gene [76, 77].

Dr. Dodds: After years of studying and researching the hematologic and immunologic diseases of animals as models for their human counterparts, I realized that I needed to look more at the body as a whole and what regulated it.