Sentences with phrase «animal models of»

After discussing similar effects in other animal models of cancer and a few studies showing the ability of antioxidants to prevent cancer growth, Campbell concluded that «a pattern was beginning to emerge: nutrients from animal foods increased tumor development while nutrients from plant - based foods decreased tumor development.»

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

DR can protect neurons against degeneration in animal models of Alzheimer's, Parkinson's and Huntington's diseases and stroke.

The neuroprotective effectiveness of blueberry and spirulina compounds has been observed in past experiments in animal models of aging and stroke.

All of these components have been observed in animal models of addiction — for sugar, as well as drugs of abuse.

This proposed role for GM1 (and indirectly GD1a) provides a rationale for its potency in suppressing diabetes in NOD mice (10) and disease onset in other animal models of autoimmunity.

Improved animal models of Parkinsonism are essential to advance our understanding of disease pathophysiology and for eventual testing of potential therapeutics.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.

The Jackson Laboratory Research scientist / Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science 2006 - present

I am particularly pleased that the fundamental knowledge of gene function and the derivation of animal models of human disease are underpinning important therapeutic advances.

Animal models of post traumatic stress disorder: behavioral characterization and pharmacological validation I. MORGANSTERN, Q. CHANG, A. CHOO, L. THIEDE, K. HOMA, E. SABATH, W. ALVINS, J. SUTPHEN, S. DAVIS, J. BELTRAN, M. KWAN, D. BREGNA, G. SMAGIN, S. LEISER, A. GHAVAMI, T. HANANIA... Abstract / Posters

Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal models of T2D.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

He has developed laboratory and animal models of the tumor in its microenvironment, which have allowed for both identification of novel targets and validation of novel targeted therapies.

Neurona's founders have discovered that certain types of neuron transplants can rebalance nervous system activity, repair neural circuits, and rescue multiple animal models of disease.

In addition, the Fletcher group investigates immunity using the mouse model and aims to develop animal models of TB disease better able to predict TB vaccine efficacy in clinical trials.

«Treatment for these people is greatly needed, and there really are very few highly valid animal models of the disorder,» said Shanahan, a postdoctoral researcher at the University of Chicago.

There are currently no disease - modifying treatments that have been shown to slow the progression or delay the onset of HD in humans; however, several compounds have demonstrated promise in animal models of HD.1 Robust and sensitive markers of disease progression are required to assess their efficacy in humans.

Now, the crucial questions are what those therapies will be and how we can ensure that they actually do in humans what they do in cells or animal models of HD.

We aim to develop a system that links gene discovery to signaling pathways and eventually to set up animal models of disease by manipulating genes of interest through mouse genetics.

Our lab makes use of animal models of either physiological or pathological remodeling to study the underlying molecular pathways of these remodeling responses.

Improve, refine and when applicable develop more relevant new animal models of chronic pain — spontaneous (and evoked

Selective 5 - hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: Identification of drugs in several animal models of CNS related disorders.

I was excited about translating our promising in vitro results into therapies, but in 2001 there were still no good small animal models of HIV infection.

So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully delaying symptom onset or even reversing symptoms.

Workshop on Animal models of Disease, focused mainly on Rheumatoid Arthritis and other chronic inflammatory diseases.

Acetylcholinesterase inhibitors have been demonstrated to improve learning and memory in a number of animal models of cognitive dysfunction, as well as being a standard of treatment in patients exhibiting clinical signs of memory loss.

These data suggest that amylin acts on the pathological cascade in animal models of AD, and further supports the therapeutic potential of amylin - type peptides for AD.

The Czech Centre for Phenogenomics and the Institute of Molecular Genetics of the ASCR, v.v.i., would like to invite you to a seminar «Gait Analysis in Animal Models of Human Disorders» presented by Dr. Thomas G. Hampton (Mouse Specifics, Inc., Boston, USA).

In view of the critical importance of these interactions in normal cardiovascular functin and disease, there has been a great need for an approach to combine in vivo measurement and imaging of paramagnetic molecules with imaging of tissue and organ biochemical and functional parameters in animal models of disease.

A unique strength of the TNC is our ability to study analogous phenotypes in rare genetic populations and the corresponding genetic animal models of disease.

The lab is working to harness this mechanism to improve the clinical outcome in animal models of the many neurodegenerative disorders that have an inflammatory component, including ALS, Alzheimer's and Parkinson's diseases.

These data should be informative for the development of future animal models of Parkinson's disease.

Lloyd Trotman's recent research path begins at his discovery some years ago that the loss of a single copy of a master tumor suppressing gene called PTEN is sufficient to permit tumors to develop in animal models of prostate cancer.

Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent.

The colorectal cancer project employs a mouse model that the researchers established with the help of Paul Grippo, an associate professor specializing in animal models of gastroenterology.

Background: Neural stem cells can reduce brain and spinal cord inflammation in animal models of MS Macrophages, called «eater» cells of the immune...

Additionally, in animal models of AD exercise improves performance on memory tasks and reduces AD - like pathology (Stranahan et al., 2012; Intlekofer and Cotman, 2013).

As one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related disease.

Among the newly funded investigations are: the development of animal models of diabetic eye disease to learn how fenofibrate, a drug clinically - approved to treat cholesterol, protects the eye from diabetes - related damage; the development of a specialized camera to capture how the retina's rods and cones (responsible for turning light energy into shapes and colors) work in health and how they fail in retinal diseases; and the exploration of mechanisms by which intestinal tract bacteria impact the health of the eye.

Objective: Exposure to phencyclidine (PCP) has been used as an inducing condition in various animal models of schizophrenia.

These projects are particularly suitable for postdoctoral scientists looking to launch an independent research career with novel animal models of eye disease in hand.

We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age - related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations.

Scientific meeting «Gene targeting, genome editing & transgenesis: research application» We are organizing joint meeting with our colleagues from Masaryk University in Brno dedicated to current progress in transgenic technologies in research application, animal models of diseases and Wnt signalling.

Dr. Francois Benard's team focuses on developing and using imaging techniques to characterise tumours in patients, and in animal models of cancer.

In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned on.

memory process; hippocampo - cortical interactions; cholinergic system; glutamatergic system; Cellular and molecular biology; hippocampal neurogenesis; animal models of Alzheimer's disease; animal models of schizophrenia

GLN - 1001 is currently in preclinical development, where it has been shown to dramatically prolong survival in patient derived xenograft animal models of glioblastoma.

We developed several computational and machine learning methods to successfully identify behavioral patterns or signatures associated with different classes of reference drugs, from which to predict the class of novel compounds (Brunner et al., 2012, Alexandrov et al., 2015), and more recently developed methods to allow us to compare animal models of AD and its progression, and to identify (in silico) novel compounds from our existing database of thousands of novel and reference compounds with the potential to reverse the AD model behavioral profile.