Sentences with phrase «animal models of the disease»

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.

These tools, coupled with animal models of disease and with the latest methodologies in genomics and proteomics, are leading to vast amounts of information about the nervous system under normal and pathologic conditions.

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease.

In the current study, published in Nature Communications, the scientists created a new animal model of disease to determine if BBB leakage can cause autoimmunity.

Research on Huntington's has thus far relied heavily on animal models of the disease, and has left many key questions unanswered.

One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies requires animal models of disease that closely replicate the human condition.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11.

Your Leader article went a long way toward describing the challenges inherent in animal models of disease (29 October, p...

The new study shows deleting Rhes significantly reduces behavioral problems in animal models of the disease.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have successfully tested a potent synthetic compound that prevents type 1 diabetes in animal models of the disease.

«We wanted to develop a newborn screen for NPC because we know that the earlier we intervene with investigational treatments in animal models of the disease, the longer the animals live,» said Ory, the Alan A. and Edith L. Wolff Distinguished Professor of Medicine.

As an experimental approach, I believe in the need for the combined molecular, behavioural and neuropathological / neuroanatomical study of animal models of disease and CNS dysfunction.

Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.

The CRISPR - Cas technology generates specific animal models of disease and is transforming model generation in mice, rats, rabbits, and larger animals.

In animal models of disease, iPSCs have been used to treat sickle cell anemia, Parkinson's disease, diabetes, spinal cord injuries, and heart failure.

Some evidence of the involvement of retinal tissue hypoxia has come from in vivo measurements in animal models of disease, though the onset of hypoxia and the severity of the insult have been difficult to identify.

For example, he discovered that reducing levels of a protein called tau can prevent cognitive deficits in animal models of the disease.

Injecting breast cancer with oxygen - filled microbubbles makes tumors three - times more sensitive to radiation therapy and improves survival in animal models of the disease.

He also showed that DBSI could be used to examine the development of white matter inflammation in patients with neurodegenerative diseases and in animal models of these diseases.

We are organizing joint meeting with our colleagues from Masaryk University in Brno dedicated to current progress in transgenic technologies in research application, animal models of diseases and Wnt signalling.

The Center for Predictive Medicine recognizes the challenges of translational research such as in designing and implementing high - throughput screens and assessing small molecules and potential vaccines for their efficacy in small animal models of disease.

Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness.

[15] AFF 1 vaccination preserved sufficient functionality to allow treated model PD mice to cling on for 19 s. Hindlimb engagement is by analogy a, particularly suggestive outcome for animal models of a disease of fine motor control impairment.

The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the disease.

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

Scientific meeting «Gene targeting, genome editing & transgenesis: research application» We are organizing joint meeting with our colleagues from Masaryk University in Brno dedicated to current progress in transgenic technologies in research application, animal models of diseases and Wnt signalling.

A unique strength of the TNC is our ability to study analogous phenotypes in rare genetic populations and the corresponding genetic animal models of disease.

In view of the critical importance of these interactions in normal cardiovascular functin and disease, there has been a great need for an approach to combine in vivo measurement and imaging of paramagnetic molecules with imaging of tissue and organ biochemical and functional parameters in animal models of disease.

Workshop on Animal models of Disease, focused mainly on Rheumatoid Arthritis and other chronic inflammatory diseases.

SAN FRANCISCO, CA — Scientists at the Gladstone Institutes have discovered that an FDA - approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's - related impairments in an animal model of the disease.

We aim to develop a system that links gene discovery to signaling pathways and eventually to set up animal models of disease by manipulating genes of interest through mouse genetics.

Neurona's founders have discovered that certain types of neuron transplants can rebalance nervous system activity, repair neural circuits, and rescue multiple animal models of disease.

An important step in developing effective treatments for human disease is finding an effective animal model of the disease to test potential therapies.

The pathogenesis, disease course, and treatment response of cOSA closely parallels that of human pediatric OSA (hOSA), and it has thus been proposed as a spontaneous animal model of the disease.

Although stem cell therapy is fairly new to veterinary medicine, it has been demonstrated to be an effective treatment in numerous animal models of disease such as osteoarthritis, tendon repair, fractures, muscular dystrophy, autoimmune problems, and other disorders.

Not exact matches

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Next, Ubogu and his team looked at an animal model of AIDP where they were able to block CD11b early in the disease process.

Nath's team is currently developing an animal model of Nodding syndrome to further study the disease and test potential therapies.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

Neurologist Malcolm MacLeod of the Centre for Clinical Brain Sciences at the University of Edinburgh and his colleagues combed through papers reporting the efficacy of drugs in eight animal disease models and checked whether the authors reported four measures that are widely acknowledged to reduce the risk of bias.