Sentences with phrase «animal models showing»

In animal models showing that NAD + contributes to longevity, a major factor has been shown to be sufficient availability of the nutrient.46, 50,51 And studies show that when enzymes that require NAD + are inactive, chromosome structure suffers and cells replicate abnormally.50

Following treatment, the animal models showed significant decreases in levels of phosphorylated tau.

After an ischemic stroke in the middle cerebral artery — one of the most common types of stroke in humans — the animal models showed much lower overall fluid intake but increased preference for alcohol over water when they did drink.

The changes in locomotor activity are associated with fluctuations of anxiety - like and depression - like behaviors, suggesting that the mutant mice may serve as an animal model showing infradian oscillations of mood substantially similar to those found in patients with bipolar disorder.

[19] Animal models show that fluoride reduces reproductive hormones in females.

Not exact matches

PPAR gamma agonists have shown strong potential in animal models related to the various phenotypes associated with X-ALD.

Studies show that these models can accurately predict the ways that new drugs will react in the human body and replace the use of animals in exploratory research and many standard drug tests.

Initial studies conducted by Christine Radtke, new Professor for Plastic and Reconstructive Surgery at MedUni Vienna / Vienna General Hospital, have shown in an animal model that the threads have great potential for nerve and tissue repair.

This week in Nature Communications, an interdisciplinary team of scientists proposes a more nuanced model for extinction that also shows why animal species tend to evolve toward larger body sizes.

New research from an international group led by Min Zhao, professor of ophthalmology and of dermatology at the University of California, Davis, shows that, in animal models of diabetes, slow healing is associated with weaker electrical currents in wounds.

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

«Cerebellar interactions with the frontal cortex in cognitive processes has never been shown before in animal models,» says Parker, UI assistant professor of psychiatry and the first faculty hire of the new Iowa Neuroscience Institute.

To find out what impact this might have on a flu epidemic, Earn and his colleagues turned to a 1982 study which showed that ferrets, a common animal model for human flu, produced more seasonal flu virus if their fevers were lowered either with painkillers or by having their fur shaved off.

«Our findings confirm in humans what has been shown in animal models — that maternal obesity has a more significant impact on the body composition of boys than girls,» said Dr. Andres.

New research from McLean Hospital neuroscientists shows in an animal model that being bullied can have long - term, dramatic effects on sleep and other circadian rhythm - related functions, symptoms that are characteristic of clinical depression and other stress - induced mental illnesses.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

In addition to discovering this mechanism, Yong and Sarkar also identified a drug — amphotericin B (AmpB)-- to reactivate microglia that in an animal model, showed a significant reduction in brain tumor growth.

A few drugs have shown promise in cell culture or animal models, but clinical trials in humans are time consuming because of the slow onset and progression of the disorder's clinical symptoms.

They were able to do so by building on an experiment showing that grafting a peripheral nerve into the space between a severed spinal cord in an animal model brought about nerve regeneration (albeit limited).

«This shows that the nanoparticle - encapsulated drug is more effective in tumor reduction than the drug alone in these animal models,» says Le.

Other projects aimed to show that animals have a theory of mind, the ability to model the thinking of others (as when we judge whether a poker player is bluffing or if a potential mate is truly in love).

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

He took his prior work and expertise in the area of gastrointestinal motility and applied it to a new animal model, the zebra fish, to show that he could do what he proposed to do and then added a new hook to get it funded.

My niece has been showing me her collection of model ANIMALS.

Using electrophysiology and pharmacological tools, the research has shown that a potassium channel, specifically the BK channel, in the central nervous system can be regulated with drugs to increase or decrease these disruptions in animal models.

In the animal model, so - called DNA crosslinkers have shown to be very efficient at this.

This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of disease that matched those of the experimental mice suggesting that they were a good animal model.

The research showed that moral decisions in the con?ned scope of unavoidable traffic collisions can be explained well, and modeled, by a single value - of - life for every human, animal, or inanimate object.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

It has been suspected in humans, and shown in animal models, that the host's immune responses can make disease worse.

This study shows that inhibiting PRMT5 can significantly improve survival in an animal model of GBM.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

CDNF has shown strong neuroprotective and even restorative properties in animal models of Parkinson's disease as well as spinal and peripheral nerve injuries.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

Their series of experiments showed that a single application of concentrated, mature B cells accelerated wound healing and improved the quality of tissue repair in both animal models.

Signs of neuronal damage around plaques also varied depending on the APOE variant the animals received, and experiments in a different Alzheimer's model in which plaques appear more slowly showed that injection of APOE4 increased levels of free, soluble A-beta in the fluid that bathes the brain.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

Experiments that model the bacteria in animal cells, for example, have shown that P. aeruginosa behaves and grows in certain ways only when it is in the infected lungs of a person with CF.

Their findings, published recently in the journal Blood, show that animal models without this enzyme experience dangerous HSC activation and ultimately succumb to lethal anemia.

When transplanted to an animal model of corneal blindness, these tissues are shown to repair the front of the eye and restore vision, which scientists say could pave the way for human clinical trials of anterior eye transplantation to restore lost or damaged vision.

Recent work by the same group of researchers showed that such disruptions in sleep were also a hallmark of fetal alcohol syndrome, both in animal models and in people.

When RNAi therapies weren't delivered to the right tissues, dangerous side effects showed up in humans that weren't predicted through animal models.

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

A series of experiments showed that SW033291 could inactivate 15 - PGDH in a test tube and inside a cell, and, most importantly, when injected into animal models.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so - called «off - target» spots on a chromosome, the development of immune cells can lead to cancer in animal models.

«In previous studies we showed that it is possible to improve long - term memory by regulating the course of the PKR protein and the eIF2 in models in young and healthy animals.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

Researchers applied mathematical models of animal locomotion to show why height gives them a competitive advantage.

The XROMM model shows that the two tendons crossing the animal's elbow behave like an archer's bowstring, powering energy into the wing beat after the muscles contract.