Sentences with phrase «animal patients from»

Each year more than 20,000 animal patients from across Illinois and beyond visit the hospital.

Not exact matches

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

In 2000, Klapper took a break from his patients at Cedars - Sinai Medical Center in Los Angeles to visit the nearby tar pits, where myriad mammals and other animals (SN: 5/17/14, p. 18) have been getting stuck for the last 40,000 years.

Scientists doing more open - ended searches often use mass spectrometry, generating lists of the extracellular vesicle — associated proteins in samples from diseased and healthy patients or animals.

In their always engrossing, often grotesque account, journalist Bill Wasik and veterinarian Monica Murphy trace the illness's history, detailing the many futile methods of combating the disease (including the original «hair of the dog:» binding into a patient's wound a hair from the animal that infected him) before Louis Pasteur's rabies vaccine became the first effective treatment in 1885.

p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients.

Researchers administering inhaled transgenic alpha - 1 antitrypsin from sheep bred by PPL discovered that some patients suffered pulmonary symptoms that caused them to leave the trial — a possible immune reaction to residual proteins from the animal that remained after purification of the drug.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

«This model is more realistic than traditional animal models because it is derived from a patient's own cells.»

Critics have long argued that transplanting animal tissue into even a small number of immune - suppressed patients could allow obscure pathogens to jump from animals to humans.

«After our animal studies showed that GM - CSF was important in the development of an MS - like disease, we were excited to see these results confirmed using samples from MS patients in the current study,» says Abdolmohamad Rostami, M.D., Ph.D., Chair of the Department of Neurology at Thomas Jefferson University and director of its neuroimmunology laboratory.

This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of disease that matched those of the experimental mice suggesting that they were a good animal model.

To conduct their study, Kaur, Baiocchi and their colleagues used tumor tissue from patients, cell lines and an animal model.

They found that their observations from animal models held true in that the average length of all the DNA pieces present in the blood from melanoma patients was 20 - 50 base pairs shorter compared to the DNA pieces in blood from healthy volunteers.

Importantly, these devices also will open up new approaches to drug development not possible with animal models today, such as personalized medicines and development of therapeutics for specific genetic subpopulations using chips created using cells from particular patients.»

All of the study patients received biological valves, developed from animal or donated human tissue.

Analysis revealed that trans fats from both animal and vegetable sources were significantly more abundant in the fat tissues of heart attack patients than in the healthy volunteers.

Sumitran - Holgersson says she hopes in future to try using blood vessels from animals for re-coating with patients» own cells, as the source would be potentially limitless.

The researchers studied the adhesion mechanisms using detailed biochemical analyses and state - of - the - art genetic systems, combined with unique H. pylori clinical strains and biopsy - materials collected from individual patients and animals over a span of many years.

«We estimate that data from millions of patients and animals may be tucked away in predatory journals,» said Dr. Manoj Lalu, associate scientist and anesthesiologist at The Ottawa Hospital, assistant professor at the University of Ottawa and co-author of the study.

The new genomic catalog contains nearly 200 viral genomes collected from patient samples in Sierra Leone and Nigeria, as well as field samples from the major animal reservoir, or host, of Lassa virus — the rodent Mastomys natalensis, also called the multimammate rat.

However, data from animal studies of Ebola, as well as studies of patients with infectious diseases such as tuberculosis, provide a sound basis for initial recommendations.

Critics charge that rabbits are not good animal models for human brain diseases and note that the dialysis patients suffered from dialysis encephalopathy, or «dialysis dementia,» not Alzheimer's disease.

At the asylum and the army barracks, he and his team also infected patients with infectious syphilis bacteria taken from humans and animals, mixed with beef heart broth, distilled water, or spinal fluid.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

Both animals die from a severe gut disease that affects some CF patients.

More animal studies would be needed to move this drug toward human clinical trials, but «what we hope is that we could use this drug to intervene in patients who have had an episode of prolonged seizures and give it to them briefly following that episode to protect them from becoming epileptic,» said James McNamara, M.D., a professor in the departments of neurobiology and neurology at Duke University.

Craig Heller and Dennis Grahn, animal physiologists at Stanford University, invented the tool to warm patients waking from anesthesia but found it also had a useful application as a cooling system.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

Because M. lepromatosis can not be grown in the lab and animal models for this version of leprosy do not exist yet, the scientists used an infected skin sample from a patient in Mexico to obtain the bacterium's genetic material.

«This is important because the iPSCs are derived directly from adult tissue and can be a perfect genetic match for a patient,» said Jose Cibelli, an MSU professor of animal science and a member of the team.

While the animals» brains experience dramatically reduced blood flow during hibernation, just like human patients after a certain type of stroke, the squirrels emerge from their extended naps suffering no ill effects.

In a new project that began this month, Drs. Anuradha Ray and Wenzel were recently awarded a five - year, $ 8 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), also part of the National Institutes of Health (NIH), to continue studying the immune response and genetic roots of severe asthma in 120 patients and in animal models.

To test this in an animal that is more closely related to humans, investigators in Japan directed iPSCs taken from a monkey to develop into certain neurons that are depleted in Parkinson's disease patients.

«By using an animal model to expand tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.

Recent evidence from population, patient and animal research suggests that aging - associated changes in the pelvic vasculature, resulting in atherosclerosis and vascular dysfunction, may be important contributing factors to LUTS.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

12:29 - Collecting all this data from HD patients and animals poses computational challenges, that Steve Horvath is working hard to fix

In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.

«This discovery is exciting because the treated fibroblasts are from diabetic patients and they work in an animal model.

Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.

The main research activity (located in central Paris and vicinity at Orsay) regroups to date 16 technology platforms and services offering state ‐ of ‐ the - art expertise and equipment from small molecule chemistry to omcs, super-resolution microscopy, sophisticated radiation sources and various animal models, including xenografts directly derived from patients, in order to promote the best environment and support for research activities.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

Conduct clinical trials in a petri dish using the actual affected human cell types — from patients rather than from surrogate models (e.g. animals).

However, adding more healthy fat, protein, and calories to the diet — whether they come from plant or animal sources — is what Dr. Dweck recommends to her patients who have very low BMIs and are missing their periods.

Insofar as we can generalize from these animal experiments to humans, they provide a potential rationale for using low - protein diets to treat cancer patients, and raise the important clinical question of how to best maintain proper detoxification in these patients.

It seems I was spending hours reading paper after paper reporting an endless stream of animal studies on this connection that, to me, have little or no practical value in terms of addressing the needs of patients suffering from behavioral or neurodegenerative disorders.

But the likely reason is not that his patients have eliminated animal products from their diets but because they've also thrown out their supersized servings of junk foods full of the sugar, starchy carbs and trans fats that have been well proven to cause heart disease.

The patient example here used to discredit the virtues of the plant based intervention approach would have likely showed massive endothelial damage from the decades of high animal protein and artery injuring foods, in fact the plant based intervention at the late stage of his chronic illness may have actually improved blood work and perhaps added some time to this patients life although it is not mentioned here.

In nature, animals naturally stop eating when they're sick, and isolated tribes still have sick - houses where patients refrain from consuming food.