Sentences with phrase «animal study designs»

However, animal study designs can also be problematic.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Not exact matches

The study wasn't about designing a new way of testing animal behavior, either; the same test has been used in rodents.

According to a study funded in part by the National Institutes of Health, companion animals — like dogs, cats or the guinea pigs in the study — may prove to be a helpful addition to treatment programs designed to help children with ASDs improve their social skills and interactions with other people.

The biomedical device company CryoLife, Inc. is now using the researchers» design to build ring implants for further studies in lab animals, Karp says.

«This study highlights the importance of confirming the validity of potential biomarkers in a relevant, large animal model and will be useful in the design of future clinical trails,» commented lead investigator Stephen J. Kolb, MD, PhD, Associate Professor, Department of Neurology and Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH.

Bioprocess engineer Rafael Garcia of ARS and biochemical engineer Zhiyou Wen of the Virginia Polytechnic Institute and State University in Blacksburg are designing a study to grow EPA - and DHA - producing microbes using low - cost by - products of other processes, such as glycerol from biodiesel production and rendered animal protein from slaughterhouses.

Guidelines exist for the appropriate design and conduct of studies in some fields, including animal research and microarray experiments.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

In the new work, W. Tecumseh Fitch of the University of St. Andrews in Scotland and Marc D. Hauser of Harvard University designed a study to test whether the animals could follow more complicated sentence structures, in which words that depend on one another are separated.

Miller and colleagues were intrigued by the possibility of designing studies to lower tau in people, but first they needed to see how the oligonucleotide worked in an animal more similar to people than a mouse.

«This work sets the stage for additional animal studies to see if tamoxifen can be used as a drug in people and will allow us to design new drugs related to tamoxifen that are better antifungals,» says Damian Krysan of the University of Rochester, an author on the study.

The measure aims to make chemical safety reviews more science - based, and includes provisions designed to reduce the use of animals in chemical testing and promote the study of so - called cancer clusters.

This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»

Update: Six French scientific academies issued a statement on 19 October, saying the Séralini study could not reverse previous conclusions that this and other GM crops are safe, because of problems with the experimental design, statistical analysis and animals used, and inadequate data.

But a new opportunity may be opening up for studies of chimpanzee behavior and cognition: A first - of - its - kind partnership between a sanctuary and a research center, announced this month, is designed to bolster the scientific output of facilities that have until now primarily focused on the long - term care of their animals.

Researchers might be less likely to register a poorly designed animal study if they know other scientists will see it, and that might stop them from conducting the study.

The authors recommend using sequencing to characterize variation within laboratory animal populations before designing studies, allowing the results to be properly interpreted.

The new policy of NIH application instructions will follow this consideration and is expecting that «sex as a biological variable will be factored into research design, analyses and reporting in vertebrate animal and human studies».

Request Service (back to top) To request Animal / Cell Core services, each user will submit a form describing the name of the project, PI and proposed study design.

Advances in our knowledge of how this complex animal develops have made possible comparative studies to identify common features of animal design and to determine how morphological diversity evolves.

Researchers from the University of California, San Diego (UCSD) School of Medicine, the Center for Neurologic Study and Isis Pharmaceutical Corporation have designed and tested a molecular therapy in animals that they hope will be a major development in the fight to treat amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

What is often overlooked is the fact that these concepts also apply to laboratory animals, making diet a critical part of study design.

Previous work by the NC3Rs showed that many publications reporting publicly funded animal research from the UK and US lacked key information on how the study was designed, conducted and analysed, which could limit their value in informing future scientific studies and policy.

In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.

RP: Study design, animal protocol approval request (IACUC), animal studies, genetic analysis, data acquisition and analysis, manuscript preparation and revision.

WRAIR and collaborators will share data related to assays designed to measure antibody responses following vaccination with ZPIV, biologic samples generated during the performance of animal studies, and biologic samples generated during the performance of early human trials assessing the safety and immunogenicity of ZPIV.

ICS is involved in international programs designed to reduce the number of animals used: Eumorphia: this program is about standardization of phenotyping procedures and statistical studies.

And even when research is put forward, it is dated, poorly designed or involves only animal studies.

As this paper from 2009 explains, the supposed link between dietary and serum cholesterol stems from studies that had fundamental design flaws, failed to separate the effects of cholesterol different types of fat intake, or were performed on animals that are obligate herbivores (hey there, rabbits!).

«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.

Over-generalizations from poorly designed, low quality in vitro and animal studies and studies that failed the test of sta...

Would be interesting to see well - designed studies comparing different «clean» (organic or the best available, though most people can't afford it and won't buy it) animal stocks (chicken, beef, lamb, pork, fish) with veggie broth.

And while specific pheromones are known to trigger specific responses in animals from bees to squid, scientists have yet to isolate them in humans, and according to Smithsonian Magazine, a review of scientific literature on the study of pheromones «found that most research on the topic was subject to major design flaws.»

Following a thorough feasibility study and cost analysis, the county arrived at a cost - effective design that provides a safe, sanitary, inviting space for both humans and animals in need, including:

«The literature review was conducted to inform the research plan and design for the remainder of the effectiveness study and to provide a resource to help understand the current status of human - animal interaction research within this domain,» said Michael McFarland, DVM, DABVP, Group Director, Veterinary Operations, Companion Animals, U.S. Pfizer Animal Hanimal interaction research within this domain,» said Michael McFarland, DVM, DABVP, Group Director, Veterinary Operations, Companion Animals, U.S. Pfizer Animal HAnimal Health.

This article describes the study design and methodology of the Western Canada Study, with emphasis on herd - selection criteria and study implementation, the collection of herd - production data, and the challenges of tracking individual animals in a large prospective observational study - as the Western Canada Study is the largest on - farm study of its kind in North American cow - calf herds to study design and methodology of the Western Canada Study, with emphasis on herd - selection criteria and study implementation, the collection of herd - production data, and the challenges of tracking individual animals in a large prospective observational study - as the Western Canada Study is the largest on - farm study of its kind in North American cow - calf herds to Study, with emphasis on herd - selection criteria and study implementation, the collection of herd - production data, and the challenges of tracking individual animals in a large prospective observational study - as the Western Canada Study is the largest on - farm study of its kind in North American cow - calf herds to study implementation, the collection of herd - production data, and the challenges of tracking individual animals in a large prospective observational study - as the Western Canada Study is the largest on - farm study of its kind in North American cow - calf herds to study - as the Western Canada Study is the largest on - farm study of its kind in North American cow - calf herds to Study is the largest on - farm study of its kind in North American cow - calf herds to study of its kind in North American cow - calf herds to date.

All Hill's supported studies are designed to preserve and improve animal health.

This program combines the study of college - level general education courses and extensive course work in science and animal health theory and practice designed to prepare graduates for careers as registered veterinary technicians.

Manuscripts reporting use of a euthanasia method (s) classified as unacceptable by the American Veterinary Medical Association or use of an anesthesia method (s) that is widely prohibited (e.g., chloral hydrate, ether, chloroform) must include at the time of initial submission, scientific justification for use in the specific study design, as well as confirmation of approval for specific use from their animal research ethics committee.

Unlike the majority of existing research in the human - animal interaction field, this rigorously designed pilot study took place at multiple sites, and incorporated a randomized control cohort and validated instruments.

Safety considerations in the design and interpretation of clinical trials indicates that «some animal studies have suggested the potential for dose - dependent fetal toxicities (for example, growth impairment, skeletal malformations and cardiovascular anomalies) associated with excess Vitamin D supplementation.

The research suggests that companion animals — like dogs, cats or the guinea pigs in the study — may prove to be a helpful addition to treatment programs designed to help children with ASD improve their social skills and interactions with other people.

Merck Animal Health (known as MSD Animal Health outside the United States and Canada) released the results of a large, well - controlled study with veterinarians designed to definitively quantify the prevalence of mental illness and stress in the veterinary profession and compare the findings to previous studies and the general U.S. population.

ACE thinks that some of HLL's early studies were not conducted as well as they could have been, and that there were problems in some of the write - ups of those studies.262 For example, HLL conducted five studies with the same participant pool, which might have caused the results of some of those studies to be influenced by earlier experimental manipulations.263 Some studies also did not include appropriate control groups, and many studies did not control for desirability bias.264 We think these early studies helped influence animal advocates to see research into animal advocacy methods as possible and desirable, but that their utility is otherwise limited by some of their design flaws.

But let's face it — as a veterinarian who spent the better part of a decade studying animal medicine, you probably don't have the time, nor desire, to get schooled in all things web design.

This research was funded by the Morris Animal Foundation (Veterinary Student Scholar Project Award) who played no role in the study design nor in the collection, analysis and interpretation of data, nor in the decision to submit the manuscript for publication.

The present study was designed to obtain input from private veterinary practitioners from around the United States concerning the skills and knowledge new graduates should have and the procedures they should be able to perform when entering small animal practice.

She is a founding member of the Human - Animal Bond Initiative, a group designed to scientifically study the interaction between humans and animals.

A three - year study of euthanasia risks in a Philadelphia - area animal shelter concluded that adult dogs are most likely to die, purebred dogs are more likely to be reclaimed by owners, and that compilation of such information is necessary for the design of community intervention programs to reduce euthanasia of dogs and cats.