The size difference between tumor and healthy circulating DNA was initially discovered in
animal tumor models created by inducing tumors with human cancer cells.
However, it was unclear at this stage in their research if this was a species - specific finding limited to
animal tumor models or if this was a biologic phenomenon that may also be present in cancer patients.
Not exact matches
Hingtgen's group is already testing how far their
tumor - homing cells can migrate using larger
animal models.
A raft of studies in laboratory
animals, molecular
models and cancer patients suggest that pain drugs given during and after cancer surgery stimulate the growth and spread of certain
tumors.
In addition to discovering this mechanism, Yong and Sarkar also identified a drug — amphotericin B (AmpB)-- to reactivate microglia that in an
animal model, showed a significant reduction in brain
tumor growth.
Again, using mouse
models of glioblastoma — this time created from brain
tumor cells that were resistant to the herpes virus — the therapy led to increased
animal survival.
Next they intend to perform studies in
animal models and in solid
tumors.
Testing each of these factors for their ability to return differentiated
tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated
tumor cells back into glioblastoma stem cells, both in vitro and in an
animal model.
The researchers took this discovery and, in an
animal model, identified a drug that is able to re-activate those immune cells and reduce brain
tumor growth, thereby increasing the lifespan of mice two to three times.
«This shows that the nanoparticle - encapsulated drug is more effective in
tumor reduction than the drug alone in these
animal models,» says Le.
BPTES has been used in
animal models for a variety of cancers but has not substantially reduced
tumor sizes, probably because the drug concentration in
tumor tissue is not high enough when using conventional drug formulation methods, say the scientists.
Its research includes a cluster of related interdisciplinary projects that examine disparities in breast cancer mortality between African - American and Caucasian women using
animal models, molecular characterization of
tumors, and behavioral research focused on social - environmental factors.
In earlier studies involving
animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a
tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.
To conduct their study, Kaur, Baiocchi and their colleagues used
tumor tissue from patients, cell lines and an
animal model.
The Oncotarget study demonstrated that Brenner's antibody worked in
animal models of
tumors that made cadherin - 11.
Researchers used IL - 15 to develop a whole
tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in
animal models; results showed that
tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.
«The result was an extensive inhibition of
tumor growth and prevention of metastasis to the lung in HER2 - positive
animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.
Morris says vaccination with modified
tumor cells producing IL - 15 and IL - 15Rα slowed
tumor growth and led to increased survival for
animal models.
In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress
tumor progression and metastatic outgrowth in an
animal model.
This was reflected in how much more efficient PMIL - delivered treatment was in the
animal models compared to either treatment alone, since PDT simultaneously sensitized the
tumor to the second therapy.
«We demonstrated that the co-administration of the iRGD peptide with the particles can enhance the effectiveness of pancreatic cancer treatment in the
tumor model, leading to increased
tumor shrinkage, disappearance of metastases and enhanced
animal survival» said Meng, an adjunct assistant professor of nanomedicine.
DNA vaccines have been studied in
animal models of viral, bacterial, and parasitic disease, as well as
animal models of
tumors.
In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of
tumor cells in
animal models in one of the hardest to treat cancers — triple negative breast cancer.
In their research, scientists at Rutgers created
animal models that closely resemble the cancerous
tumors found in women with ovarian cancer by injecting
tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.
Researchers gave
animal models an oral supplement of spermidine and found that they lived longer and were less likely than untreated individuals to have liver fibrosis and cancerous liver
tumors, even when predisposed for those conditions.
In
animal models, the modified T cells greatly reduced the
tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.
«
Animal model for pediatric brain
tumor created.»
«We had previously shown that antiangiogenesis therapies were ineffective in
animal models of lymphatic metastasis, but there was no data to explain the mechanism behind those observations,» says Timothy Padera, Ph.D., of the Steele Laboratory of
Tumor Biology in the MGH Department of Radiation Oncology, senior author of the paper.
These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted
tumor growth in
animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.
When using a well established
model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the
animals more susceptible to developing colonic
tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.
Now, they have demonstrated its success in an
animal model — the drug shrank the
tumor and increased survival.
«By using an
animal model to expand
tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.
But based on studies in
animal models of pancreatic cancer, U-M researchers and colleagues theorized that dissemination happens before we
tumors can be detected.
URBANA, Ill. — Years of research in University of Illinois scientist John Erdman's laboratory have demonstrated that lycopene, the bioactive red pigment found in tomatoes, reduces growth of prostate
tumors in a variety of
animal models.
Using
animal models and cells, Counter and colleagues found that when they experimentally inhibited copper uptake by
tumors with the BRAF mutation, they could curb
tumor growth.
In a previous study, Lonard and co-senior study author Bert O'Malley of Baylor College of Medicine screened a large number of compounds to identify SRC - inhibiting molecules that kill a wide variety of cancer cells and inhibit
tumor growth in
animal models.
Now we want to extend this technology to
animal models, such as cancer bearing mice, to verify its practical use in different types of
tumors,» explains Park.
Brain
Tumor, Pediatric High Grade Gliomas, Histones, Epigenome, Cancer Genomics, Giant Cell
Tumors of the Bone,
Animal Models
«This is exciting because it's the first
animal model of pediatric high - grade gliomas, or malignant brain
tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.
In addition, previous studies done in Wang's lab suggest that BCX, through a different molecular mechanism, can slow the nicotine - promoted growth of lung
tumors and decrease cigarette smoke - induced lung inflammation in
animal models.
[31]
Animal brain metastasis
models have demonstrated significant
tumor response and improved survival with this compound.
Injecting breast cancer with oxygen - filled microbubbles makes
tumors three - times more sensitive to radiation therapy and improves survival in
animal models of the disease.
The technology has been demonstrated in
animal models and also in human breast
tumors.
The lab has examined MRI cell tracking in
animal models of dysmyelination, multiple sclerosis, brain
tumors, spinal cord, stroke, and diabetes.
Other
animal models either express oncogenes in a tissue - specific manner or shut down the expression of
tumor suppressor genes in the whole tissue.
Antibody Targeting of Long - Circulating Lipidic Nanoparticles Does Not Increase
Tumor Localization but Does Increase Internalization in
Animal Models
Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed
tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in
tumor vasculature, to investigate the virus's mechanism of action in
animal models.
Jun. 14, 2017 — A PET probe that detects the amino acid glutamine predicts whether
tumors respond to certain targeted therapies in preclinical
animal models.
Their work encompasses several strategies, including: developing FL - HCC
animal models to characterize
tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
Lloyd Trotman's recent research path begins at his discovery some years ago that the loss of a single copy of a master
tumor suppressing gene called PTEN is sufficient to permit
tumors to develop in
animal models of prostate cancer.