Sentences with phrase «anthrax toxins»

She remained in Sheffield to complete a PhD and short post-doc in the lab of Professor Beining Chen, primarily working to screen and characterise small molecule inhibitors of anthrax toxins as part of a collaboration with the Health Protection Agency at Porton Down.

Scientists have been working for decades to understand how anthrax toxins get into cells; recently researchers have started exploring the possibility of mimicking this system to deliver small protein molecules as vaccines.

The gene produces a protein that is embedded in the membrane of cells, and is known to bind anthrax toxins internalizing them into the cell where they exert their action.

Until now, however, scientists have been unsure how the anthrax toxin proteins control tumor growth.

In a paper appearing in the journal ChemBioChem, Pentelute and colleagues showed that they could use this disarmed version of the anthrax toxin to deliver two proteins known as antibody mimics, which can kill cancer cells by disrupting specific proteins inside the cells.

To circumvent this problem, the investigators examined in mice whether a regimen of the chemotherapy drugs pentostatin and cyclophosphamide (PC) could block production of the antibodies that neutralize the anthrax toxin proteins.

Together, the results showed that the combined anthrax toxin protein and PC therapy has durable, anti-tumor effects worthy of further exploration, according to the authors.

In this study, NIH scientists used mouse models to show that anthrax toxin proteins work by specifically targeting the cells that line the inner walls of the blood vessels feeding the tumor.

The anthrax toxin has three major components.

January 23, 2002 Structure of anthrax toxin offers clues to treatment Researchers describe the 3 - D structure of edema factor, one of the three toxins that make anthrax so deadly.

Not exact matches

Based on highly credible intelligence, UNSCOM [the U.N. weapons inspectors] suspects that Iraq still has biological agents like anthrax, botulinum toxin, and clostridium perfringens in sufficient quantity to fill several dozen bombs and ballistic missile warheads, as well as the means to continue manufacturing these deadly agents.

Although much of that money goes to stockpiling vaccines and improving disease surveillance and information exchange, part of it pays for research into improved vaccines and other «countermeasures» against smallpox, anthrax, and botulinum toxin.

Even so, the identification of an LF target molecule represents the first step toward identifying compounds that can counteract the toxin — which could be a boon if the anthrax bacillus were to be used in a terrorist attack.

Like anthrax, diphtheria and botulism, C. diff infection is a toxin - mediated disease.

Then there's Iraq, where the government spent $ 80 million over 20 years on bombs that its scientists knew would not deliver most of the anthrax and other toxins they contained, but simply destroy them on impact.

High on the list: ways to neutralize the anthrax bacterium's fiendish toxin

The GAO audited laboratory safety oversight following errors that could have exposed dozens of people to live anthrax bacteria and the deadly toxin ricin.

Researchers at Sandia National Laboratories are developing a medical instrument that will be able to quickly detect a suite of biothreat agents, including anthrax, ricin, botulinum, shiga and SEB toxin.

Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down - regulates immune functions.

«In this way, the fabric will be able to block chemical agents such as sulfur mustard (blister agent), GD and VX nerve agents, toxins such as staphylococcal enterotoxin and biological spores such as anthrax.»