Sentences with phrase «anti-hiv microbicides»

A series of vaccine and microbicide clinical trials to prevent HIV transmission have been unsuccessful, and scientists are returning to the drawing board to devise new approaches.

Researchers leading a large, ongoing study in women called VOICE that compares PrEP with pills to a vaginal microbicide plan to revaluate the ethics of continuing to use a placebo control group given the new evidence of oral Truvada's powerful impact.

As reported online this week in Science and in a presentation at the 18th International AIDS Conference in Vienna, of the 444 women who received a placebo gel, 60 became infected with HIV versus 38 infections in the 445 women who received the microbicide.

Another application could be their development into crèmes or gels (i.e. microbicides) that prevent transmission of viruses like HIV during sexual intercourse.

The largest study ever conducted of a microbicide designed to prevent HIV infection has resulted in yet another case of high hopes being dashed about a promising product.

That $ 90 million study, financed by the U.S. National Institutes of Health (NIH), startled many in the field who, based on other failures of nonspecific microbicides, had predicted the product would do nothing.

McCormack says the data mark the end of the road not just for this vaginal gel but the whole class of microbicides that use nonspecific compounds to prevent HIV - infection.

The U.S. National Institute of Allergy and Infectious Diseases provided the main funding for ASPIRE, which was run by the Microbicide Trials Network that Hillier heads.

But the most promising candidates — compounds called vaginal microbicides that thwart the virus at the site of infection — have failed repeatedly in clinical trials.

«This [set of studies] was the last hope for microbicides in many ways,» says Thomas Hope of Northwestern University's Feinberg School of Medicine in Chicago, Illinois.

When the gel comes in contact with semen, the change in pH causes it to reliquefy and release an HIV - killing microbicide.

Where budgets are limited, they suggest money should be allocated first to increasing male circumcision, then to more frequent HIV screening, use of vaginal microbicides and increasing antiretroviral therapy.

These include voluntary male circumcision — now recommended by the World Health Organization and Joint United Nations Programme on HIV / AIDS as a preventive strategy — as well as vaginal microbicides and oral pre-exposure prophylaxis, all of which confer only partial protection against HIV.

«I don't think anyone suspected that the tenofovir gel would not work,» says immunologist John Moore, who works on microbicides at Weill Cornell Medical College in New York City.

After the microbicide showed promise in test - tube experiments, Haase's team moved on to rhesus macaques.

«I'm very pleased that the answer was so clear,» says the University of Pittsburgh's Sharon Hillier, who heads the Microbicide Trials Network that is conducting VOICE.

Unlike soap - based microbicides, GML is not a so - called surfactant that aims to disrupt the viral membrane, says Haase.

Rhesus macaques like this one blocked the monkey version of HIV with a new microbicide.

The researchers decided to test a microbicide that contains glycerol monolaurate (GML), a fatty acid that has proven safe in many products: It's used as a fiber finish in tampons and also as an emulsifier in many foods and cosmetics.

For 20 years, AIDS researchers have searched for a vaginal microbicide that can block HIV, but they have made little progress.

Now a new monkey study suggests that a microbicide containing a compound that many investigators would consider old - fashioned may have the power to thwart the AIDS virus.

Today, most microbicides in human studies or on the drawing board contain anti-HIV drugs that cripple a critical viral enzyme.

The failure of first - generation microbicides has led the field to largely abandon the strategy behind them: that HIV could be stopped by compounds, such as soaps, that disable the virus without specifically attacking it.

In addition to the expanded use of ARVs in new modalities such as pre-exposure prophylaxis and microbicides [1], this includes commensal microbicides [2], gene therapies [3], [4] and vaccines [5], [6], [7].

Funding: This work was supported by the European Commission sixth Frame Work Programme as part of the European Vaccines and Microbicides Enterprise (EUROPRISE), the European Commission seventh Frame Work Programme as part of the Combined Highly Active Anti-retroviral Microbicides project (CHAARM)[to RAW], the Bill and Melinda Gates Foundation as part of the Collaboration for AIDS Vaccine Discovery (CAVD grant 38637 [to RAW] and grant 1032144 [to MSS]-RRB-, and the UK Medical Research Council [RAW and AF].

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

His contributions to microbicides for HIV prevention spans two decades and culminated in the CAPRISA 004 tenofovir gel trial which provided proof - of - concept that antiretroviral drugs can prevent sexually transmitted HIV infection and herpes simplex virus type 2 in women.

Among other grants, he has participated to several EC - FP6 funded grants (AVIP, NEAT, Europrise) and coordinated the «GISHEAL» program on the genetics and immunology of HIV long term nonprogressors; he has also participated to the FP7 - funded project «AIM - HIV» on microbicide discovery.

Professor Abdool Karim is a member of the UNAIDS Scientific Expert Panel and Scientific Advisor to the Executive Director of UNAIDS, Scientific Advisory Board member of the US President's Emergency Pan for AIDS Relief (PEPFAR), Chair of the PEPFAR Adolescent Girls and Young Women Expert Working Group, a member of the HIV Centre Strategic Advisory Committee and the NIH OAR Microbicides Planning Group.

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration of infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides

The ongoing Cape Town congress is itself a sign of change, aimed at bringing together researchers pursuing their different aims in vaccines, pre-exposure prophylaxis, and microbicides along with community members, policymakers, and advocates.

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: B This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpri

Restricted to use by members of the European Vaccines and Microbicides Enterprise and for use within Europe.

Shattock himself is currently undertaking research into the potential effects of combining a microbicide and an experimental vaccine candidate.

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.4 SUBTYPE: BF1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e6.2 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Ent

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr

James Eghaghe The New HIV Vaccine and Microbicide Research Advocacy Society of Nigeria (NHVMAS), Nigeria

Interim data from a parallel open - label study of the ring called HOPE, led by the US National Institutes of Health - funded Microbicide Trials Network (MTN), reported nearly identical results today at CROI.

HIVR4P supports cross-fertilization among research on HIV vaccines, microbicides, PrEP, treatment as prevention, and other biomedical prevention approaches, while also providing a venue to discuss the research findings, questions, and priorities specific to each.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

«Because SEVI can so greatly enhance HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness,» Greene explained.

Dr. Zeda Rosenberg, who leads the International Partnership for Microbicides, argued in Bangkok that a microbicide to protect women from HIV could be available within five years.

Community members and leading and upcoming Ugandan scientists engaged in dialogue on issues surrounding HIV vaccines, microbicides and pre-exposure prophylaxis (PrEP).

We tried to address some of these issues while working on an RNAi - based microbicide to prevent sexual transmission of viral infection (and ultimately HIV) in mice.

Results from an initial study combining a microbicide candidate and experimental vaccine are promising enough to at least keep Imperial College virologist Robin Shattock coming back for more in pursuing what could be a novel move in preventing HIV infection.

The Resource Tracking for HIV Prevention R&D Working Group (RTWG), led by AVAC, in partnership with the International AIDS Vaccine Initiative and UNAIDS tracks trends in R&D investments and expenditures for biomedical HIV prevention options, including AIDS vaccines, microbicides, multipurpose prevention technologies, pre-exposure prophylaxis (PrEP), treatment as prevention, medical male circumcision, female condoms, HSV - 2 vaccines, HIV cure and therapeutic vaccines.

Researchers from the University of Nebraska - Lincoln have generated an «on - off switch» into a weakened form of HIV, potentially creating a new vaccine for Comprehensive exploration of research into HIV prevention, including microbicides, PrEP, PEP, condoms, circumcision and HIV treatment as prevention.

Learn about HIV prevention Comprehensive exploration of research into HIV prevention, including microbicides, PrEP, PEP, condoms, circumcision and HIV treatment as prevention.

Tags for this Online Resume: Engineer, hands on, product development, automation, LSR, microbicides