Sentences with phrase «anti-epithelial cell adhesion»

The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter protein set and the process of learning as well as between a cell adhesion set and the process of memory storage.

Aiolos decreases the production of cell adhesion proteins and disrupts critical cell adhesion processes, including processes that allow tissue cells to anchor to their physical environment, a necessary requirement for cells to survive and spread.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

Neuronal cell - glial cell adhesion was inhibited by prior incubation of the neurons with Fab» fragments of antibodies to neuronal membranes.

In contrast, antibodies to the neural cell adhesion molecule (N - CAM) did not inhibit the binding.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

Cells can fail to stick together sufficiently, referred to as reduced cell adhesion, or they can stick together normally but not respond in the correct way to that contact, referred to as a loss of contact inhibition.

The apCAM's are members of the immunoglobulin class of cell adhesion molecules and resemble two neural cell adhesion molecules, NCAM and fasciclin II.

This rapid, transmitter - mediated down - regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long - term synaptic facilitation.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

«We can incorporate cell adhesion or degradation sites to recruit cells or draw in different components from native tissue.»

Dr. Islam's discovery was published [S. Islam, T. E. Carey, G. T. Wolf, M. J. Wheelock, and K. J. Johnson, «Expression of N - Cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell - cell adhesion,» J. Cell Biol.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

They coat the pad with a layer of anti-epithelial cell adhesion molecules (anti-EpCAM) which bond with CTCs but not with normal cells.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

For instance, Georgia Tech Graduate Student Ricardo Cruz - Acuña, the paper's co-lead author, experimented with several combinations before determining that a hydrogel made up of 96 percent water and containing a particular cell adhesion peptide was ideal for the HIOs.

The good news is that restoring normal levels of nitric oxide can substantially reduce red blood cell adhesion, said Dr. Tohru Ikuta, a molecular hematologist at the Medical College of Georgia at Georgia Regents University.

Rather, restoring normal nitric oxide levels appears the most efficient, effective way to reduce red blood cell adhesion, the researchers write.

Researchers found that histatin - 1 promotes angiogenesis, as well as cell adhesion and migration.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

More of the antibodies that coat the nanorod can therefore bind receptors on the surface of endothelial cells, and that leads to more effective cell adhesion and more effective drug delivery.

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.

In fact, the researchers found gene expression differences between ASD and non-ASD in genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cycle.

This week at the Biophysical Society 59th annual meeting, being held Feb. 7 - 11, 2015 in Baltimore, Md., University of Illinois biophysicists are reporting a new picture of cell adhesion mechanics they liken to a famous Hans Christian Andersen fairy tale.

This gene plays a role in cell adhesion in the brain.

To better imitate cells» real environment in human body, researchers evenly mixed weak (rupture force of 12 pico - Newtons) and strong (rupture force of 54 pico - Newtons) tension gauge tethers and studied cell adhesion in the multiplex scenario.

«In our prior studies, tension gauge tethers with different tension tolerances were individually presented to cells, and we found the universal threshold force for integrin - mediated cell adhesion is around 40 pico - Newtons,» Roein - Peikar said.

They found a gene — dubbed Dscam (Down syndrome cell adhesion molecule)-- that appears to give every nerve cell a unique identity during prebirth development, making sure that each cell ends up in the right location in the brain and body.

In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling, cell adhesion and cytoskeleton dynamics required for tumor invasion.

Researchers at the Mechanobiology Institute have comprehensively described the network of proteins involved in cell - cell adhesions, or the cadherin interactome.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

↵ 3 The abbreviations used are: HUVEC, human umbilical vein endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated cell sorting; FGFR, fibroblast growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.

The constitutive and inducible expression of the endothelial cell adhesion molecules E-selectin, ICAM - 1, and VCAM - 1 was assessed by immunohistochemistry (Figs. 4, A — C) ⇓.

The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.

When primary cultures from these mice are stimulated with proinflammatory cytokines, the endothelial cell fraction responds by up - regulating the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1.

In particular, the research identified several genes regulated by methylation in the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo development.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

To extend the idea of cell adhesion being like a «cellular handshake», imagine walking along a crowded street while holding hands with a partner.

Interestingly, the researchers found that most of the proteins that associated with E-cadherin did so independently of cell - cell adhesion.

Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

To determine inducible endothelial cell adhesion molecule expression (E-selectin, VCAM - 1, and ICAM - 1), some of the chambers were given medium containing 10 ng / ml TNF - α for 4 — 6 h (these time points were selected to correlate with the known kinetics of endothelial cell adhesion molecule expression; Refs.

With the E-cadherin interactome now described in detail, researchers can finally step back and view the complex picture that is cell - cell adhesion.

The most prominent cell - cell adhesion complex is the Adherens Junction.

The ability to up - regulate endothelial cell adhesion molecules after exposure to cytokines was unaffected by repeated subculturing of cells, because we noted identical staining patterns for passage 30 cells (we did attempt to extend this observation to include later passage cells).

Despite their importance in cell - cell adhesion, scientists have yet to fully understand how the cadherin - catenin - actin complex forms and is regulated.

The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.