In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to
the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancer.
Not exact matches
However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with
anti-estrogen drugs like
tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.
Two types of
anti-estrogen drugs
Tamoxifen (Nolvadex) and raloxifene (Evista) are part of a drug class called selective estrogen receptor modulators (SERMs).
For example, the
anti-estrogen drug
tamoxifen, prescribed for breast cancer treatment, has been used by men to oppose the estrogenic effects of anabolic steroids.