Sentences with phrase «anti-neural cell adhesion molecule»

In contrast, antibodies to the neural cell adhesion molecule (N - CAM) did not inhibit the binding.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

The apCAM's are members of the immunoglobulin class of cell adhesion molecules and resemble two neural cell adhesion molecules, NCAM and fasciclin II.

This rapid, transmitter - mediated down - regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long - term synaptic facilitation.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

They coat the pad with a layer of anti-epithelial cell adhesion molecules (anti-EpCAM) which bond with CTCs but not with normal cells.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.

They found a gene — dubbed Dscam (Down syndrome cell adhesion molecule)-- that appears to give every nerve cell a unique identity during prebirth development, making sure that each cell ends up in the right location in the brain and body.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

↵ 3 The abbreviations used are: HUVEC, human umbilical vein endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated cell sorting; FGFR, fibroblast growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.

The constitutive and inducible expression of the endothelial cell adhesion molecules E-selectin, ICAM - 1, and VCAM - 1 was assessed by immunohistochemistry (Figs. 4, A — C) ⇓.

The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.

When primary cultures from these mice are stimulated with proinflammatory cytokines, the endothelial cell fraction responds by up - regulating the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.

To determine inducible endothelial cell adhesion molecule expression (E-selectin, VCAM - 1, and ICAM - 1), some of the chambers were given medium containing 10 ng / ml TNF - α for 4 — 6 h (these time points were selected to correlate with the known kinetics of endothelial cell adhesion molecule expression; Refs.

The ability to up - regulate endothelial cell adhesion molecules after exposure to cytokines was unaffected by repeated subculturing of cells, because we noted identical staining patterns for passage 30 cells (we did attempt to extend this observation to include later passage cells).

Pilot studies using a variety of strategies suggested that this goal could be best achieved by stimulating primary organ cell cultures with TNF - α (10 ng / ml) and targeting cells expressing the endothelial cell adhesion molecules E-selectin and VCAM - 1 through a FACS - driven strategy.

Nectin - 4 is a cell adhesion molecule that is expressed on a number of solid tumor cells.

In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation.

This locus contains a conserved non-coding element (CNE) upstream of three neuronal cell adhesion molecule (NCAM) genes, where the derived «sand» allele appears to disrupt a neuronal transcription factor binding motif.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Neural cell adhesion molecule (NCAM) marks adult myogenic cells committed to differentiation.

Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons.

The anti-inflammatory actions of platelet endothelial cell adhesion molecule - 1 do not involve regulation of endothelial cell NF - $ ąppa $ B.

Many of the lysosomal proteases are active at neutral pH and this would mean that they could potentially cleave cell surface receptors and cell adhesion molecules.

Almost all of these small neurons were identified to be cerebellar granule cells based on their morphology and that they were stained by anti-neural cell adhesion molecule L1 (Fig. 1A)[19].

His research interests have included the immunogenetics of diabetes, the biology of tumour - associated antigens and cell adhesion molecules, and ethical aspects of the design of trials involving human subjects.

Other studies have shown that a family of proteins called 14 -3-3 are involved in learning along with interesting cell adhesion molecules of the integrin family and the immunoglobulin superfamily.

Dr. Zutter focuses on the role of cell adhesion molecules in host - tumor interactions.

Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).

61/3: 00 Rare copy number variants implicate neuronal cell adhesion molecules in Tourette Syndrome.

Genome - wide association studies have identified associations between body mass index and two loci near cell adhesion molecule 1 (CADM1) and cell adhesion molecule 2 (CADM2), which encode membrane proteins that mediate synaptic assembly.

Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory - motor neuronal pathways.

By utilizing the tools of cell and molecular biology, he studies the mechanisms by which chemical (for example, specific cell adhesion molecules) or mechanical signals (for example, cyclic strain) are sensed by cells and alter their proliferation and specialization to either promote tissue growth or destruction.

This research has centered on biomarkers of inflammation including interleukin - 6 (IL - 6), vascular cell adhesion molecule - 1 (VCAM - 1), and lymphocyte function - associated antigen - 1 (LFA - 1).

We therefore conducted a cross-sectional analysis to investigate the relations between magnesium intake and plasma concentrations of inflammatory and endothelial biomarkers, including CRP, IL - 6, soluble TNF - α receptor 2 (sTNF - R2), E-selectin, soluble intercellular adhesion molecule 1 (sICAM - 1), and soluble vascular cell adhesion molecule 1 (sVCAM - 1) in apparently healthy women.

Besides promoting immunogenicity of the thyroglobulin molecule, dietary iodine can enhance levels of reactive oxygen species (ROS), which lead to expression of cell adhesion molecules (ICAM - 1) that are crucial to the early phases of thyroid follicular inflammatory responses (3).

The release of inflammatory cytokines, or intercellular signaling molecules such as interleukin - 1 (IL - 1), interleukin - 2 (IL - 6), and tumor necrosis factor alpha (TNF - α) at the site of immune activation causes other immune cells migrating throughout the lymphatic vessels of the body to express more cell adhesion molecules (CAMs).

Two molecules that are known to increase during inflammatory disease processes — vascular cell adhesion molecule - 1 (VCAM - 1) and intercellular adhesion molecule 1 (ICAM - 1)-- have also been shown to decrease in amount following intake of EVOO.

One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white blood cells from the blood to the arterial wall by vascular cell adhesion molecules (42).

Programs with research emphasis on signal transduction in development and oncogenesis, cell adhesion molecules in development and oncogenesis, muscologskeletal atrophy and countermeasures, ovarian follicle development, neural regeneration, implantable therapeutic or diagnostic devices and application of computers in veterinary education.

Not exact matches

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA.

Now a more fine - grained picture of adhesion mechanics is emerging, thanks to a new tool developed in Illinois in recent years called a «tension gauge tether,» which allows scientists to measure cell mechanics at the single - molecule level.

«This finding reveals cells» ultra-sensitivity for strong single molecule forces in the environment during adhesions,» Roein - Peikar noted.