Not only were the mice protected from lethal doses of flu virus, but the protection was also in large part due to the absence of familiar
antibodies against the head, the researchers found.
Not exact matches
With no
head in place to hoard the immune response, the vaccine might coax the body to make enough stem - focused
antibodies to protect
against flu, the researchers hoped, regardless of the seasonal mutations occurring at the top.
Most traditional vaccines generate
antibodies against the hemagglutinin
head.
A Switzerland - wide team of researchers
headed by the University of Zurich and University Hospital Zurich conducted an extensive study on the factors responsible for the formation of broadly neutralizing
antibodies against HIV.
As HAI
antibodies only target the «
head» of the HA while ELISA
antibodies can be
against the
head or the relatively conserved «stalk» domain, this result indicated that some individuals were more likely to target the conserved stalk region (i.e. show greater reactivity in ELISA than in HAI).
Unlike
antibodies elicited by annual influenza vaccinations, most neutralizing
antibodies induced by pandemic H1N1 infection were broadly cross-reactive
against epitopes in the hemagglutinin (HA) stalk and
head domain of multiple influenza strains.
May 29, 2015 Pembrolizumab shows real promise
against head and neck cancer Immunotherapy with the anti-PD-1
antibody pembrolizumab (Keytruda ®) was effective in one out of four patients with recurrent or metastatic
head and neck cancer, according to results presented at the 2015 meeting of the American Society for Clinical Oncology (ASCO).