Sentences with phrase «antibodies directed»

According to Cambridge Life Sciences, antibodies directed against native DNA were first detected in the serum of patients with SLE in the 1950s.

Hypothyroidism is commonly caused by an auto - immune response; that is, the body creates antibodies directed against the thyroid glands causing their destruction.

Autoimmune disease means that a dog's immune system has incorrectly identified some substance in the body as a foreign intruder, and is creating antibodies directed against the dog itself (autoantibodies), rather than the bacteria, viruses, etc. against which they should be directed.

Ninety percent of patients have antibodies directed against the H + / K + - ATPase pump.

Antibodies directed against gastric intrinsic factor result in cobalamin deficiency; this is called pernicious anemia.

The flexibility and customizability of the new indirect EasySep ™ Release Positive Selection Kits enable researchers to use antibodies directed to virtually any targets of their choice.

Annotated protein expression profiles are performed using single antibodies as well as independent antibodies (two or more independent antibodies directed against different, non-overlapping epitopes on the same protein).

iTeos has a broad pipeline focused on multiple complementary mechanisms of action including small molecules targeting IDO1, A2A, and STING as well as antibodies directed to TIGIT and Galectin 3.

Vigdorovich and colleagues developed a system to screen monoclonal antibodies directed at B7x and found one that inhibited the growth of B7x - expressing tumors.

Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4 - binding site epitopes.

Antibodies directed against amyloid beta have been able to successfully clear plaques and reverse cognitive deficits in mouse models.

Sperm - ZP binding was largely inhibited by glycoconjugates terminated with sialyl - Lewisx sequences or by antibodies directed against this sequence.

Scientists previously have shown that antibodies directed at the stem stop a diverse array of influenza viruses from causing an infection, and some are being developed as treatments.

About 3 decades ago, scientists discovered a collection of signposts: antibodies directed at certain proteins in the body, including insulin.

In addition, the researchers found that most of these children have high levels of potent and broadly neutralizing antibodies directed against HIV.

A small number of people infected with HIV produce antibodies with an amazing effect: Not only are the antibodies directed against the own virus strain, but also against different sub-types of HIV that circulate worldwide.

Breastfeeding provides the neonate with considerable amounts of secretory IgA antibodies directed particularly against the microbial flora of the mother and her environment.

Solanezumab is an antibody directed against the mid-domain of the harmful, AD - causing A-beta peptide.

James P. Allison and Matthew Krummel demonstrate that a monoclonal antibody directed against the CTLA - 4 molecule in a mouse model of melanoma could result in the rejection of tumors and that this rejection also resulted in immunity to a second exposure to tumor cells.

HIV - 1 envelope monoclonal antibody directed towards the CD4 - binding site of HIV - 1 gp120.

To further validate our inclusion / exclusion co-localization analysis we then stained rat brain sections with MAOB - 2, a monoclonal antibody directed to residues 1 — 4 of Aβ, and which has been reported as absent of cross-reactivity with APP or CTFs [39].

Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA but parvalbumin, calbindin and calretinin are also commonly used as markers to narrow down the specific interneuron subtype.

Excess colloidal gold - labeled antibody migrates across to the control line, where an antibody directed to the gold - labeled antibody binds to it.

She explained that when you give a vaccine antigen, which is the protein of the virus or bacteria you're immunizing against, you actually neutralize any existing antibody directed specifically against that same antigen.

Not exact matches

Most of the action is coordinated by white blood cells, which direct the lines of attack like football coaches, churning out antibodies that target the opponent for destruction.

And the antibodies that a direct breastfeed provides give protection against germs in the current environment, germs that might not have been present when the milk was pumped a few hours ago.

And the antibodies that a direct breastfeed provides give protection against germs in the

Bilirubin screening: Infants whose mothers are Rh negative should have cord blood sent for a Coombs direct antibody test; if the mother's blood type is O, the cord blood may be tested for the infant's blood type and direct antibody test, but it is not required provided that there is appropriate surveillance, risk assessment, and follow - up.

Dogs do not have antibodies in their blood directed against most of these.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Jinal Bhiman, a PhD student in the Faculty of Health Sciences is the lead author of the study, titled: Viral variants that initiate and drive maturation of V1V2 - directed HIV - 1 broadly neutralizing antibodies.

Further, the study showed a direct correlation between levels of Tfh cells and antibody response.

Among the protagonists are B cells, which produce antibody molecules able to neutralize pathogens or mark them for destruction, and T cells, which prompt infected cells to kill themselves or secrete chemicals that direct the activities of other immune players.

Infectious disease researchers have identified a novel mechanism wherein HIV - 1 may facilitate its own transmission by usurping the antibody response directed against itself.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

«This is an important demonstration of the possibilities opened up for immunotherapy by DMAb technology to direct in vivo production of antibodies of major relevance to human cancer,» said David B. Weiner, Ph.D., executive vice president of The Wistar Institute, director of The Wistar Institute Vaccine & Immunotherapy Center, W.W. Smith Charitable Trust Professor in Cancer Research, and senior author of the study.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

«IdeS ® could change the way we treat antibody rejections overall,» said Jordan, who also directs the Human Leukocyte Antigen and Transplant Immunology Laboratory at Cedars - Sinai.

It may well be that the antibodies found by the team weren't directed against the Heartland virus but some other agent; it's not uncommon for cross-reactivity to occur in serological tests.

It's also possible that the antibodies were directed against another virus, as Fish suggests, he acknowledges — but if so, it would be a closely related and unknown phlebovirus, which still would be something to watch closely.

Pincus, 57, studies the interaction of antibodies and pathogens and directs the Research Institute for Children at the hospital.

«We can use this cell - growth test to select for a lot of things — including the discovery of antibodies with potential medical uses — but Dr. Lerner and I wanted a more direct and generally applicable way of selecting for antibody function,» Zhang said.

It is not yet known whether the dramatic and selective effects of the NGF antibodies are due to a direct toxic action of the antibodies on immature sympathetic neurons or to an inactivation by the antibodies of circulating molecules of NGF, thereby indirectly causing the death of the sympathetic neurons by depriving them of the NGF they need in order to survive.

Clinical samples were also sent to an outside laboratory (Focus Diagnostics, Cypress, CA) for respiratory viral testing by centrifugation - enhanced shell vial culture followed by direct fluorescent antibody staining for 8 viruses (respiratory syncytial virus, adenovirus, influenza virus A and B, parainfluenza virus types 1, 2, and 3, and human metapneumovirus).

Commercial arrays are not available for all biomarkers, so customised arrays for the analysis of vaccine candidates will be developed, featuring antigens for direct detection or antibodies for sandwich immunoassays (e.g. for cytokine detection).

The first monoclonal antibody for cancer (rituximab, Rituxan, directed to CD20 on B lymphocytes) is approved for the treatment of non-Hodgkin lymphoma by the FDA.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

Analyzing this woman's virus for their current study, the researchers found that it contained mutations in four amino acids in the envelope protein, two of which, when introduced into unrelated strains of HIV in the laboratory, rendered each virus sensitive to a number of antibodies produced in people infected with HIV, including those directed to more conserved regions.

Moderna's mRNA Therapeutics ™ platform builds on the discovery that modified mRNA can direct the body's cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs with therapeutic activity inside and outside of cells.

Her own analysis of blood from narcoleptic patients vaccinated with Pandemrix revealed no clear evidence of self - directed antibodies.