Sentences with phrase «antibody affinity maturation»

Understanding such antibody affinity maturation is a key part of vaccine development.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

Not exact matches

The antibodies were from cells that had undergone extensive affinity maturation.

More specifically, rabbits have two antibodies in affinity maturation mechanisms: gene conversion and hypermutation, as opposed to mice where no gene conversion occurs.

Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation).

We would like to see some evidence that EBI2 expression in DCs affects antibody production / GC formation / affinity maturation in a polyclonal response.