Sentences with phrase «antibody drugs»
"Antibody drugs" refer to medicines that are made from special proteins called antibodies. These drugs are designed to help our immune system fight against diseases or harmful substances in our body. Full definition
Conventional immune analysis technologies fail to provide the detailed insights that are needed to create the next generation of antibody drugs.
gigagen.com
Several antibody drugs have been developed to target other receptors found on cancer - cell surfaces.
This enables therapeutic antibody drugs to bind with extreme precision — only their target molecule should be an exact match.
Bioanalysis of antibody drug conjugates using LBA / LC - MS and the BioBA Solution Bioanalysis Zone 25 October 2016
Adding the monoclonal antibody drug trastuzumab — already used to treat certain breast cancers — to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value.
A new antibody drug called aducanumab appears to sweep the brain clean of sticky amyloid - beta protein.
The trial data hint that an anti — β amyloid antibody drug called aducanumab warded off cognitive decline in people diagnosed with early Alzheimer's.
Lead researcher, Professor David Allsop, commented: «Following results this summer, there is renewed optimism for antibody drugs — treatments that harness the body's immune system to target amyloid plaques.
These chips could also be used to evaluate antibody drugs and other immunotherapies, which are difficult to test thoroughly in animals because they are designed to interact with the human immune system.
GigaGen is advancing a pipeline of first - in - class biotherapeutics, including novel oncology antibody drug combinations and the world's first recombinant polyclonal hyperimmune gammaglobulin.
To see whether blocking CD47 could reverse plaque buildup, the group tested the experimental anticancer antibody drug in several different mouse models of cardiovascular disease.
Many existing drugs for rheumatoid arthritis are expensive protein therapies, such as the blockbuster antibody drug Remicade (infliximab), marketed in the United States by Centocor of Horsham, Penn., which earned about $ 6 billion in global sales in 2009.
In the meantime, simply giving patients more prolonged exposure to IL - 2 could improve the effectiveness of existing antibody drugs, Wittrup says.
Wittrup and his colleagues made the discovery that they could generate both types of immune responses while they were experimenting with improving antibody drug performance with a signaling molecule called IL - 2, which helps boost immune responses.
A follow - up clinical study is currently underway at Rockefeller to assess whether offering antibody drugs to patients receiving ART can help reduce or alter their HIV reservoirs.
«We wondered if we could render anthrax toxin nontoxic, and use it as a platform to deliver antibody drugs into cells.»
This is shiny new technology, and it's used to manufacture the three drugs that pharmaceutical forecasters predict will be this year's top - selling medicines — the monoclonal antibody drugs Humira (adalimumab) and Remicade (infliximab), and Enbrel (etanercept), another kind of biologic known as an Fc fusion protein.
Grifols is a world leader in production of polyclonal antibody drugs.
Finally, yet another phase 3 study — albeit one with less encouraging results — found that the monoclonal antibody drug cetuximab (Erbitux) did not aid people with (potentially curable) early - stage colon cancer if they carried the normal form of the KRAS gene.
In tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a week.
In this 42 - patient, ovarian cancer study, DPX - Survivac is being combined with Keytruda (pembrolizumab), Merck's anti-PD monoclonal antibody drug.
A new antibody drug may reverse the dangerous buildup of fatty plaque (shown in gray in the cross-section above) on artery walls (orange).
These chips could also be used to evaluate antibody drugs and other immunotherapies, which are difficult to test thoroughly in animals because the treatments are only designed to interact with the human immune system.
Trianni and GigaGen entered into a co-discovery contract for immuno - oncology antibody drugs.
Accomplishments: * Actively consulting on, discovery and development of Antibody Drug Conjugates (ADCs) * Actively consulting on, small molecules process optimization, scale - up and regulatory aspects * Sepsis diagnostic kits (mAb based) business to Asia for development, manuf.
Earlier this month, the FDA approved two other treatments for multiple myeloma, including another kind of monoclonal antibody drug (the same class of drug that elotuzumab is in).
Denosumab, a fully human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.
Instead of attaching a drug to an antibody, they made the antibody itself their drug.
Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.
Antibody drugs for cancer, which include rituximab and Herceptin, are believed to work by binding to cancer proteins and blocking the signals that tell cancer cells to divide uncontrollably.
They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.
Groundbreaking findings, published online in the journal journal Cancer Cell, show that resistance to many types of antibody drugs can be overcome by preventing cancer cells from «hiding» from immune cells.
These antibody drugs block receptors on T cells that tumors use to hide from the immune system.
The next generation of antibody drugs to enter the clinic will contain new technologies and enhancements to improve the properties required to clear plaques, while keeping the rest of the brain safe.»
Pembrolizumab, an antibody drug already used to treat other forms of cancer, can be effective in the treatment of the most common form of mesothelioma, according to a new study led by investigators from the Perelman School of Medicine at the University of Pennsylvania.
These are being targeted through four key platforms — immuno - oncology, the genetic drivers of cancer and resistance, DNA damage repair and antibody drug conjugates — with a strong focus on combinations.
Antibody drugs have redefined modern treatment of immune dysregulation.
Antibody drug conjugates (ADCs) represent a challenge for bioanalytical scientists, due to their inherent heterogeneity (i.e., different Drug - to - Antibody Ratios), high molecular weight, presence in complex biological matrices and changes in ADC composition in biological samples.
Post says the study is a new take on monoclonal antibody drugs that have been used in humans.
Senior manager and director of pharmaceutical process chemistry, manufacturing and controls (CMC) specializing in cGMP, quality and regulatory compliance of novel small and large molecule therapeutic drugs including peptides, nucleotides, protein biologics and antibody drug conjugates (ADCs).
Tags for this Online Resume: Chemical Process Development, API, cGMP Manufacture, Technology Transfer, Management, Quality, Risk Assessment, Pharmaceutical Operations, FDA and ICH Drug Regulations, CRO, CDMO and CMO Oversight, CMC Process Chemistry, TrackWise QMS, Change Controls, Deviation Management, Investigations, Root Cause Analysis, CAPA, Antibody Drug Conjugates, IND, IMPD, NDA, MAA and BLA