Sentences with phrase «antihelmintic mebendazole»

In a previous paper published in ecancermedicalscience, the ReDO researchers examined the anti-cancer properties of the drug mebendazole, an over-the-counter treatment currently used for threadworm.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

Tan Z, Chen L, Zhang S. Comprehensive modeling and discovery of mebendazole as a novel TRAF2 - and NCK - interacting kinase inhibitor.

Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.

Long - term follow - up of plasma mebendazole levels and drug interactions.

XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts.

Correspondingly, the in vivo growth of hedgehog - dependent medulloblastoma was inhibited by orally administered mebendazole.

A prominent example is the proposal to implement anthelminthics, such as mebendazole, niclosamide and pyrvinium pamoate, as novel anticancer drugs.

Dosing of mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM for continuous administration) with coefficients of variation ranging from 27 to 72 %.

In human cells, mebendazole suppressed the formation of the primary cilium, a microtubule - based organelle that functions as a signaling hub for Hh pathway activation.

The benzamidazole mebendazole significantly inhibited growth of adrenocortical carcinoma cells, both in vitro and in vivo, the effects being due to induction of apoptosis [19].

Furthermore, the host of different targets described seems to be linked to the capability of the benzimidazoles (mebendazole), salicylanilides (niclosamine) and cyanine dye derivatives (pyrvinium) to interact with DNA directly.

The anthelmintic drug mebendazole inhibits growth, migration and invasion in gastric cancer cell model.

Several studies demonstrated potent antitumor properties of mebendazole (Table 1).

Nygren P, Larsson R. Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer.

Anticancer activities of anthelminthics were reported for mebendazole by Mukhopadhyay et al. in 2002, for pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and for niclosamide by Wang et al. in 2009, respectively [8 - 10].

Examples of drugs identified as high - potential agents within the Repurposing Drugs in Oncology (ReDO) project include mebendazole, cimetidine, nitroglycerin, diclofenac and clarithromycin, among others [3].

Oral administration of mebendazole in mice elicited a strong antitumor effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with paclitaxel - treated mice [9,20].

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma.

Moreover, mebendazole inhibited invasion and migration of cancer cells in vitro, and formation of metastases in vivo in experimental animals.

The existing therapies that will be combined in the METRICS study are metformin, statins, doxycycline, mebendazole and ibuprofen, but it was by no means a straightforward process to land on these particular medicines.

In the conventional world of medicine, one of the mainstays is mebendazole.

Treatment involves deworming with one of several products: mebendazole (Telmintic ®), fenbendazole (Panacur ®), pyrantel pamoate (Nemex ®, Drontal ®, or Strongid T ®).

Reducing intestinal nematode infection: efficacy of albendazole and mebendazole (Review).