Sentences with phrase «antiviral defense»

It also took Ding deeper into his fundamental premise — «If RNAi remains as an effective antiviral defense in plants, insects and nematodes after their independent evolution for hundred millions of years, why would it stop working with mammals?»

«There are many different antiviral mechanisms in our bodies, but maybe RNAi functions as the most important antiviral defense mechanism.

Greber suspects that the nucleus has antiviral defense reactions, akin to the cytosol, and these defense reactions are variable between cells.

The evidence reported in the Cell Press journal Cell Reports on November 21st shows that the drug called Amphotericin B, which has an estimated $ 330 million in sales around the world each year, can render a protein important for antiviral defense ineffective in both cells and mice.

Once tagged, RIG - I triggers the production of antiviral defense molecules known as interferons.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

The findings, which were featured in a Science cover story in 2002, showed that RNAi is a common antiviral defense in plants, insects and nematodes, and explained why viruses have to keep a protein to suppress that defense.

Previous studies had established that antiviral defense triggered by RIG - I depends on the protein's proper intracellular localization and transport, which are mediated by a partner - protein called 14 -3-3 epsilon.

«When these are sensed, an immediate antiviral defense is launched.

Emerging evidence indicates that the RNAi and related pathways function in many fundamental biological processes, including antiviral defense, development, and maintenance of genomic stability (Liu, 2003 and references therein).

His current research on the CRISPR system for antiviral defense has had a major impact on the field.

Whether or not RNAi contributes to antiviral defense in mammals has been uncertain.

«It's certainly within the realm of possibility that if peroxisomes play this key role in antiviral defense, it may be possible to take drugs that are known to boost peroxisome production to provide protection against the viruses,» says Hobman.

Baulcombe «was among the few, at least in Europe, who was entertaining the idea that one... biological role [of silencing] was in fact an antiviral defense mechanism,» Voinnet says.

Based on his results, and published studies on the B2 protein of Flock house virus, an insect pathogen, Ding proposed in a 1995 paper that 2b and B2 proteins act by suppressing the host's antiviral defense.

According to the scientists, this phenomenon may be part of the antiviral defense reaction.

Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.