Primary
congenital aphakia is a rare development disorder, characterized by the absence of lens developed between the 4th and the 5th week of embryogenesis.
A study of Valleix et al. (2006) identified homozygous mutation of FOXE3 gene on 1p33 chromosome in three brothers
with aphakia born by consanguineous parents.
Secondary aphakia concerning in partial development of the lens due to late reabsorption or eventually due to expulsion through a corneal perforation (1).
The Infant Aphakia Treatment Study began in 2004 (
aphakia refers to an eye without a lens).
But another reason that aphakic dogs can not be compared to aphakic humans,
where aphakia is devastating to vision, is that dogs do not have the area of retina called a fovea so the impact on vision is not the same.
Many pets still function quite well
despite aphakia though obviously this situation is not optimal for vision.
Congenital aphakia is often associated with other secondary eye abnormalities such as aplasia / dysplasia of the anterior chamber of the eye, microphtalmia, absence of the iris, retina dysplasia (1, 2).
It's a world of vision that it is difficult to imagine, but we might get some clues from people
with aphakia: a condition in which the lens of the eye — which normally absorbs UV light before it can reach the retina — has been removed in surgery or lost in an accident.
Congenital
aphakia is a rare anomaly.
Detection of neuronal loss using T1rho MRI assessment of 1H2O spin dynamics in
the aphakia mouse.