The results suggested that each of the Wnt genes (Wnt - 2b, Wnt - 8c, Wnt - 3a) were responsible for turning on two forms of FGF, each of which controls both limb initiation and a bud or bulge known as
the apical ectodermal ridge (AER), which acts as the «organizer» of limb development.
Both groups report that a strand of rapidly dividing cells on the tip of the growing vertebrate limb, called
the apical ectodermal ridge (AER), arises exactly on the border between cells that switch on R - fng and those that don't.