Indicated are
apical microvilli (AMv), melanin - containing melanosomes (red arrows), the basal nucleus (N), desmosomes (white arrows) and basal lamina (black arrows).
Akin to human RPE, the cells were highly polarized with basal nuclei,
apical microvilli and adherens junctions (Fig. 2C and 2D).
Here we address how polarized enterocytes harboring actin - rich
apical microvilli undergo extensive cell remodeling to drive injury repair.
Through its F - actin - severing activity, the microvillar actin - binding protein villin drives both
apical microvilli disassembly in vitro and in vivo and promotes lamellipodial extension.