Sentences with phrase «aplastic anaemia»

High prolonged levels of oestrogen in the body can cause aplastic anaemia.

«We provide proof - of - concept that the telomerase based treatment -LRB-...) has a therapeutic effect on the type of aplastic anaemia caused by short telomeres,» the authors state in an article in the journal Blood, with Christian Bär among them as the first author, as well as Juan Manuel Povedano.

There are types of aplastic anaemia that are not associated with short telomeres.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anaemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

INHERITED AND ACQUIRED Aplastic anaemia can be caused by inherited mutations in about thirty genes (known to date), several of which are involved in preserving the telomeres.

Now, the same researchers have proven that this therapy may be effective against the types of aplastic anaemia caused by short telomeres.

Representative bone marrow images of aplastic anaemia (left) and cured anaemia upon the telomerase gene therapy (right).

This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia

One of them was used to reproduce acquired aplastic anaemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace.

«In the group that was not treated with the gene therapy, the majority of the animals die from aplastic anaemia, and they also die much sooner.»

A common trait in aplastic anaemia, regardless of whether it is inherited or acquired, is the presence of short telomeres.

The second animal model attempts to reproduce hereditary aplastic anaemia, which is produced by mutations associated with the telomeres and telomerase.

It is a completely new strategy against aplastic anaemia.