Sentences with phrase «apolipoprotein ai»

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

Second question my husband had labs and is on Crestor and had to add another med because triglycerides 264, 8 out of ten lipoprotein particles and apolipoproteins are high and inflammation oxidation myeloperoxidase is 503 yikes.

Not exact matches

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Apolipoprotein E is a protein that is important in the repair and recovery of brain cells that have been damaged due to concussion.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

(Apolipoprotein E-ε4 is the top risk gene for Alzheimer's.)

A large - scale genetic analysis in PSP patients, however, identified a common tau sequence that increases by 5.5 times a person's chances of developing the disease, making this variant a stronger risk factor for PSP than one copy of the apolipoprotein E-ε4 variant is for Alzheimer's.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

Instead, a blood protein known as apolipoprotein B (apoB) is a truer indicator of the threat to our arteries, the doctors say.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Until recently, only four genes associated with late - onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE - e4, having the largest effect on risk.

Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection.

Until recently, only one gene variant, Apolipoprotein E-e4 (APOE - e4), had been confirmed as a significant risk factor gene for the common form of late - onset Alzheimer's disease, which typically occurs after age 60.

There are four know AD genes: (1) Amyloid precursor protein gene (APP); (2) Presenilin 1 gene (PSEN1); (3) Presenilin 2 gene (PSEN2); (4) Apolipoprotein E gene (APOE).

Nox2 modification of LDL is essential for optimal apolipoprotein B - mediated control of agr type III Staphylococcus aureus quorum - sensing.

The goal of this project is to elucidate the functional role of apolipoprotein E (APOE) in microglia, the resident immune cells of the brain.

Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Keywords: Alzheimer disease, antioxidants, apolipoprotein E, oxidative stress, presenilin, s - adenosylmethionine

The editors of JLR will pay close attention to the Spotlight Talks, as the journal is just wrapping up an eight - review series on the major risk factor for Alzheimer's disease, apolipoprotein E, and it's time to get inspired for the next one.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.»

were used to examine the potential association between VRF scores and the change in MMSE and CDR - SB scores, adjusting for age, sex, and the apolipoprotein ɛ 4 allele (APOE4).

E-Scape Bio is now developing small - molecule drugs that target the primary genetic cause of Alzheimer's disease by correcting adverse effects of the apolipoprotein E4 (apoE4) gene.

The interest intensified several years ago with the surprising discovery that an increased risk of Alzheimer's disease was linked to a natural genetic variant of a key fat - transporter molecule called apolipoprotein E, or apoE.

Two renal - risk variants in the apolipoprotein L1 gene (APOL1), termed G1 and G2, are present in a large percentage of African American organ donors and kidney transplant recipients.

Led by Michael Holzer at the Institute of Experimental and Clinical Pharmacology, the research team went on to determine that «prolonged freezing at -20 °C or -70 °C led to a shedding of apolipoprotein - AI from HDL and to the formation of large protein - poor particles, indicating that HDL is irreversibly disrupted.»

In 1999, he was named an Alexander Hollaender Distinguished Fellow where he identified a novel apolipoprotein (ApoA5) involved in human and mouse triglyceride metabolism.

The talk was entitled «What is an apolipoprotein?»

Apolipoprotein (APOE) genotyping with oversampling of ε4 + individuals will be used to enrich the enrollment sample, such that roughly half of those scanned will be amyloid positive and half will be amyloid negative.

Background Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late - onset Alzheimer disease (LOAD).

At apolipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for MI.

Involved in the initial discovery of apoE as a major apolipoprotein regulating lipoprotein metabolism, including that apoE is induced by fat / cholesterol feeding in atherogenesis.

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

Lipoprotein (a)- lowering interventions could be preferentially effective in reducing the risk of coronary heart disease in individuals with smaller apolipoprotein (a) isoforms.

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C - III (ApoC - III) levels.

Finally, we compared phenotypic versus genotypic ORs to estimate whether apolipoprotein (a) isoform size, lipoprotein (a) concentration, or both were causally associated with coronary heart disease.

PI (4,5) P2 is translocated by ABCA1 to the cell surface where it mediates apolipoprotein A1 binding and nascent HDL assembly, and it is carried on HDL.

The abnormal composition of apolipoproteins (apo) in the lipoprotein fractions from the patient (P) is compared with the compositions of his mother (M) and a normolipidemic control participant (C).

The investigators also found that eating one or more fish meals a week was linked to less Alzheimer's damage in the brain, but only among people with a gene variant called apolipoprotein E (APOE).