Sentences with phrase «apolipoprotein e4»

Keywords: Alzheimer's disease, apolipoprotein E4, apoptosis, cathepsin D, lysosomes, thioredoxins

E-Scape Bio is now developing small - molecule drugs that target the primary genetic cause of Alzheimer's disease by correcting adverse effects of the apolipoprotein E4 (apoE4) gene.

Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid - beta (Aβ) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains.

Dr. Mahley, along with Gladstone Investigator Yadong Huang, MD, PhD, will use the funding to identify new chemical compounds that can target apolipoprotein E4 (apoE4)-- the strongest genetic risk factor for developing Alzheimer's.

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction.

Dr. Huang studies the origin and development of Alzheimer's disease, focusing on the pathological role of apolipoprotein E4 (apoE4)-- the major genetic risk factor for Alzheimer's.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

Not exact matches

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Until recently, only four genes associated with late - onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE - e4, having the largest effect on risk.

Until recently, only one gene variant, Apolipoprotein E-e4 (APOE - e4), had been confirmed as a significant risk factor gene for the common form of late - onset Alzheimer's disease, which typically occurs after age 60.

Depressed neurofilament expression associates with apolipoprotein E3 / E4 genotype in maturing human fetal neurons exposed to HIV - 1.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

People with one copy of the variant, called apolipoprotein E-e4 (APOE e4), have a 29 % lifetime risk of developing Alzheimer's disease, while people who don't have it have a 9 % risk.

The two most striking risk factors appear to be hyperinsulinism and possession of one or two E4 alleles for the apolipoprotein E gene (ApoE4), which is involved in lipid processing.

Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. NEJM 1996; 334 (12): 752 - 758.