Sentences with phrase «apolipoproteins apoe2»

Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects.

Effect of a single oat bran cereal breakfast on serum cholesterol, lipoproteins, and apolipoproteins in patients with hyperlipoproteinemia type IIa.

Second question my husband had labs and is on Crestor and had to add another med because triglycerides 264, 8 out of ten lipoprotein particles and apolipoproteins are high and inflammation oxidation myeloperoxidase is 503 yikes.

Comparison of the effects on lipoproteins and apolipoproteins of a diet high in monounsaturated fatty acids, enriched with avocado, and a high - carbohydrate diet.

But the study found only the fish oil influenced HLD cholesterol by altering the production catabolism rate of HDL apolipoproteins (catabolism is the breakdown of complex molecules metabolically into simpler ones).

Effect of thyroid hormone replacement on lipoprotein (a), lipids, and apolipoproteins in subjects with hypothyroidism.

Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins.

The abnormal composition of apolipoproteins (apo) in the lipoprotein fractions from the patient (P) is compared with the compositions of his mother (M) and a normolipidemic control participant (C).

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

Neurons try to avoid this damage by secreting these lipids, and apolipoproteins — proteins that transport lipids — carry them to glia cells.

Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL - cholesterol, and apolipoprotein - B in young men and women

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Apolipoprotein E is a protein that is important in the repair and recovery of brain cells that have been damaged due to concussion.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

HDL with a small proinflammatory protein called apolipoprotein C - III (apoC - III) on its surface may nearly double the risk of heart disease in healthy men and women, according to Frank Sacks, professor of cardiovascular disease prevention at the Harvard School of Public Health and senior author on a paper in the April Journal of the American Heart Association.

After secretion, apolipoprotein E and cholesterol associate with high - density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor - mediated endocytosis.

We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in «reverse cholesterol transport.»

(Apolipoprotein E-ε4 is the top risk gene for Alzheimer's.)

In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E.

A large - scale genetic analysis in PSP patients, however, identified a common tau sequence that increases by 5.5 times a person's chances of developing the disease, making this variant a stronger risk factor for PSP than one copy of the apolipoprotein E-ε4 variant is for Alzheimer's.

Cholesterol - loaded macrophages secrete cholesterol and apolipoprotein E.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte cells that seems to help spur nerve cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.

In «Greater Cognitive Deficits with Sleep - Disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis,» researchers report that study participants carrying the apolipoprotein?

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

«Approximately 15 percent of the human population carries apolipoprotein APOE4.

Apolipoprotein E comes in three versions, or variants, called ApoE2, ApoE3 and ApoE4.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

The REVEAL team recruited subjects who had a parent or sibling suffering from AD and who had signed up to learn about their apolipoprotein E, or APOE, genotype.

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

Humans carry a gene for a protein in cells called apolipoprotein E, which helps clear amyloid - beta from the brain by binding to it and breaking it down.

«Our previous work showed that compared to APOE3, the apolipoprotein produced by the APOE4 gene does not bind well to amyloid - beta and so does not clear the neurotoxin from the brain.»

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

With the same diet pattern, levels of LDL cholesterol and apolipoprotein B (a secondary end point) increased, with no changes in HDL cholesterol or triglyceride level or blood pressure.»

Instead, a blood protein known as apolipoprotein B (apoB) is a truer indicator of the threat to our arteries, the doctors say.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Long - term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics — Ida Rune — Scientific Reports

Long - term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics

Expression of apolipoprotein E mRNA in the epithelium and interstitium of the testis and the epididymis.

Apolipoprotein EWIKIMEDIA, PROTEIN DATA BANK / J.

So, the researchers attached a fragment of apolipoprotein B to glucocerebroside, hoping that it would transport the enzyme into the brain.

Abbreviations: LDLR = LDL receptor; APOB / A1 = apolipoprotein B - 100 / A1; PCSK9 = proprotein convertase subtilisin / kexin type 9; SREBP - 1 / 2 = sterol regulatory element - binding protein 1/2; LPL = lipoprotein lipase; FATP2 / 4/5 = fatty acid transporter protein 2 / 4/5; FASN = fatty acid synthase; SCD5 = stearoyl - CoA desaturase 5; ACADL = acyl - CoA dehydrogenase; L - FABP = liver fatty acid - binding protein; and CPT1A = carnitine O - palmitoyltransferase 1.

The gene encodes a protein called apolipoprotein E.

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

Until recently, only four genes associated with late - onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE - e4, having the largest effect on risk.

Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection.