Sentences with phrase «apoptosis by»

Protection against in vivo focal myocardial ischemia / reperfusion injury - induced arrhythmias and apoptosis by hesperidin.

(2007) Concentration - Dependent Protection of Retinal Ganglion Cells From Pressure - Induced Apoptosis by Pre-Treatment With a Flavonol Flavonoid (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4944).

Gadd45b mediates Fas - induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor

Cells were gated on forward and side scatter followed by Lin (CD3, CD11c, B220, GR - 1 and NK1.1)- and Thy1.2 + CD127 + cells were analyzed for apoptosis by Annexin V and 7 - AAD staining or for necrosis using viability eFluor780 dye.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

The SUMO ligase PIAS1 regulates UV - induced apoptosis by recruiting Daxx to SUMOylated foci % U http://jcs.biologists.org/content/early/2012/09/07/jcs.110825.short.

IG20 (MADD splice variant - 5), a proapoptotic protein, interacts with DR4 / DR5 and enhances TRAIL - induced apoptosis by increasing recruitment of FADD and caspase - 8 to the DISC.

In many cancers, p53 is prevented from triggering apoptosis by its attachment to BCL - xL.

In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a tumor suppressor and an oncogene (33, 34).

So alpha - lac may induce apoptosis by directly causing the destruction of DNA from within the cell's nucleus, or it may instigate the suicide - generating caspace cascade through the mitochondria.

Not exact matches

Made of a polymer that has already been approved by the FDA for applications such as biodegradable sutures, InVivo's implant seems to undermine the biological ripple effect that leads to apoptosis, essentially by leading the body to believe that the damage is not that bad, which tones down the immune response and helps the healthier neural tissue survive and heal.

By sequencing the tumorous hydra's DNA, they discovered a gene that halts apoptosis.

Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM.

Goji's are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis.

It looks like capsaicin is able to pull this off by instructing the mitochondria in cancer cells to undergo apoptosis, cell suicide.

Gervais was so impressed by the apoptosis research that he later approached Nicholson about doing a postdoc in his lab, which is based at the Merck Frosst Center for Therapeutic Research.

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until they transition to a programmed death mode called apoptosis.

The nanovesicles fuse with tumor cells, causing them to self - destruct by apoptosis.

Rather, the group speculates that the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).

This process, called apoptosis, is triggered in oocytes by the protein p63.

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

The protein, called Bcl - 2, is already famed among biologists for its ability to block «apoptosis,» or cell suicide, the process by which damaged or obsolete cells destroy themselves.

Particularly prominent in the RNA - Seq analysis was the up - regulation of a number of granzymes, a group of proteinases secreted by immune cells that were originally thought to be involved in killing (via apoptosis) virus infected cells or other target cells.

When a cancer cell dies by apoptosis, the result is a neat and tidy process where the dead cell's remains are «recycled,» not contaminating healthy cells around them, and not inducing inflammation.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of cell suicide known as apoptosis when exposed to agents that induced ER stress.

At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity through closer collaborations and interactions with scientists studying apoptosis and cell regulation.

Tübingen researchers in a team headed by professor Ana García - Sáez of the Interfaculty Institute of Biochemistry are helping to explain important steps in the process of apoptosis.

Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell - survival proteins (survivin, Mcl - 1, XIAP or cIAP2).

Lieberman, Dotiwala and their team were particularly struck by how much the granzyme - sparked cascade resembles apoptosis, a controlled form of cellular suicide that helps eliminate damaged or potentially cancerous cells.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

The drug, birinapant, sensitizes the CA125 - negative cells to the chemotherapy by restoring apoptosis, or programmed cell death, said Dr. Sanaz Memarzadeh, a senior author of the study and a UCLA gynecologic cancer surgeon.

But he believes that targeting cancers for destruction by necrosis and not by apoptosis, the other main pathway to cell death, holds great promise therapeutically.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

«We found that when apoptosis was impaired, for instance by loss of BIM, the BET inhibitors were no longer effective,» he said.

The experiments performed by postdoctoral researcher Dr Xu revealed that BET inhibitors principally act to kill cancer cells through the process of apoptosis, or programmed cell death.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

Those cells escape from the apoptosis process by activating a cell - survival mechanism called autophagy.

The mitochondrial pathway of cell death (apoptosis) starts by permeabilization of the mitochondrial outer membrane which becomes peppered with small holes.

By invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the celBy invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the celby preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the cell.

But some cancer cells have a way to avoid apoptosis that is induced by chemotherapy.

Researchers found TRIF signaling is able to eliminate these aberrantly activated astrocytes by apoptosis, a suicide program of the cells.

The drug, known as HRX9, works by preventing the cancer cells from avoiding apoptosis — the natural process by which unhealthy and damaged cells close themselves down and die.

The other 1 million or so oocytes present at birth die off gradually by programmed cell death, or apoptosis, until a woman reaches menopause at mid-age.

The results were that BES enhanced cell survival and prevented the apoptosis of NPCs caused by growth factor deprivation.

Mice engineered to lack either a PAH receptor or the gene that causes apoptosis weren't harmed by injections of PAH, but normal mice lost most of their egg cells.