Sentences with phrase «apoptosis regulators»

What Sattler did focus on at Abbott was the structural biology of apoptosis regulators, such as the Bcl2 protein family.

To study the underlying apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.

Members of a family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance gene products.

Not exact matches

Previously, Jonathan Tilly, a reproductive biologist at Massachusetts General Hospital in Boston, found a striking correlation between high levels of a protein called Bax (a key regulator of apoptosis) and cell death in healthy ovaries.

Cytotoxicity was enhanced by alterations of the regulators of apoptosis, such as Bcl2 / XIAP, in melanoma, lung cancer and adrenocortical carcinoma [9, 19, 21, 67].

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

Although a non - essential amino acid in normal cells, the demand for glutamine is dramatically increased throughout malignant transformation to support increased metabolic demands; namely, provision of catabolic substrates for ATP production and anabolic substrates for macromolecule biosynthesis.The intracellular glutamine pool is also critical for sustained activation of mTORC1 signalling, a master regulator of cell growth and protein translation, as well as prevention of apoptosis