Sentences with phrase «apoptosis through»

Melanoma Differentiation Associated Gene - 7 / Interleukin - 24 Promotes Tumor Cell - Specific Apoptosis through Both Secretory and Nonsecretory Pathways

Since TNFα is such a potent inducer of apoptosis through TNFR1 death domain signaling, and amiodarone treatment results in the down regulation of TNFα with concomitant upregulation in TNFR2 signaling in NSC alone, it is possible that amiodarone selectively kills NSCs by lowering the threshold of TNFα required to trigger apoptosis in NSCs via upregulation of TNFR2 pathways in NSCs and not dopaminergic neurons.

Notably, genes thought to induce and promote apoptosis through the intrinsic mitochondrial apoptotic pathway, such as KLF10 [32], were not altered in differentiated cells or in treated versus untreated cells.

15 - deoxy - Δ12, 14 - prostaglandin J2 (15d - PGJ2), a prostaglandin derivative, has shown its anti-tumor activity by inducing apoptosis through reactive oxygen species (ROS)- mediated inactivation of v - akt, a murine thymoma viral oncogene homolog, (AKT) in cancer cells.

Thus, ROS - mediated JNK activation may contribute to apoptosis through down - regulation of the p - Akt and PKA - PLK1 pathways.

Titles: 1) Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

Thioredoxin - 1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the regulation of apoptosis through the inhibition of apoptosis signal - regulating kinase - 1 (Ask - 1).

ApoE4 treatment induced in addition apoptosis through translocation of Death - domain associated protein - 6 (Daxx) from the nucleus to the cytosol, suggesting an activation of the Ask - 1 pathway.

Independent of MMP activity, TIMP - 1 can promote growth and inhibit apoptosis through various pathways, including P13K and PKA [9] and, furthermore, TIMP - 1 is able to provide β cell - specific pro-survival effects [5, 6, 10].

Hong - Gang Wang, PhD (D Club) Lois High Bestler Professor of Pediatrics and Pharmacology; Director, Pediatrics Molecular Oncology Program «Ca2 + induced apoptosis through calcineurin dephosphorylation of BAD» Science, April 1999 860 citations, Web of Science, April 1, 2017

In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.

p38 MAP kinase pathway regulates apoptosis through phosphorylation and up - regulation of BimEL: ProQuest.

Bertoli, C., Copetti, T., Lam, E. W., Demarchi, F. & Schneider, C. Calpain small - 1 modulates Akt / FoxO3A signaling and apoptosis through PP2A.

Histone deacetylase inhibitors prevent p53 - dependent and p53 - independent Bax - mediated neuronal apoptosis through two distinct mechanisms.

p38 MAP kinase mediates arsenite - induced apoptosis through FOXO3a activation and induction of Bim transcription.

Not exact matches

Thus, capsaicin might commit tumors to survival and evade apoptosis in the absence of TRPV1 through the activation of EGFR.

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

Giving the mice antibiotics helped gemcitabine kill tumor cells, increasing the number of tumor cells going through a type of cell death called apoptosis from about 15 percent to 60 percent or more.

So alpha - lac may induce apoptosis by directly causing the destruction of DNA from within the cell's nucleus, or it may instigate the suicide - generating caspace cascade through the mitochondria.

At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity through closer collaborations and interactions with scientists studying apoptosis and cell regulation.

«Most chemotherapies kill cancer cells through apoptosis, and the cancer cells that escape apoptosis are the root cause of chemotherapy resistance and tumor progression,» said Chi.

The experiments performed by postdoctoral researcher Dr Xu revealed that BET inhibitors principally act to kill cancer cells through the process of apoptosis, or programmed cell death.

«In modern biology mitochondria are considered to be much more than the powerhouse of the cell; they integrate multiple intracellular signals to regulate progression through the cell cycle and into apoptosis.

«New approach for AIDS: Lock HIV in reservoir cells, to die through apoptosis.»

When L - HIPPO was added to virus - infected cells via a carrier called α - CDE, the virus became confined within the cell and the cell would die through natural apoptosis.

The cells then die naturally through apoptosis (cell death).

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Effects of miR -145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.

Effects of microRNA - 146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF -?

Live fluorescence and transmission - through - dye microscopic study of actinomycin D - induced apoptosis and apoptotic volume decrease.

Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.

The tumor suppressor p53 is critical in the protection of cells against radiation - induced carcinogenesis, most likely through its ability to trigger apoptosis of radiation - damaged cells (45).

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Phosphatase and tensin homologue (PTEN)- induced putative kinase 1 reduces pancreatic β - cells apoptosis in glucotoxicity through activation of autophagy.

The DEP domain - containing protein TOE - 2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms.

It was shown that VPA could induce the apoptosis of activated T cells and maintain immune homeostasis through the caspase - 8 / caspase - 3 pathway (28).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

We then examined whether VPA regulated immune homeostasis and ameliorated GVHD through inducing apoptosis of CD4 + T cells in vivo.

Chen Y, Liu J, Yuan B, Cao C, Qin S, Cao X, Bian G, Wang Z and Jiang J. Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through fas - and mitochondria - mediated pathways.

Manuscripts that increase our understanding of the processes through which stem cells and progenitors differentiate into committed progeny, the commitment cell death programs such as apoptosis and necrosis, aging, and the transition between proliferation and cell cycle arrest are welcome.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

Additional work, however, revealed that in collaboration with TNFR1, TNFα can act upon TNFR2 through a ligand passing mechanism and trigger apoptosis [40].

Inecalcitol, an analog of 1,25 D 3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system.

Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered apoptosis in colon cancer cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer cells.

Ma H, Liu B, Feng D, Xie H, Li R, Yuchi Y, Wang H, Wang J. Pinus Massoniana Bark Extract Selectively Induces Apoptosis in Human Hepatoma Cells, Possibly Through Caspase - dependent Pathways.

Liu J, Bai J, Jiang G, Li X, Wang J, Wu D, Owusu L, Zhang E, Li W. Anti-tumor Effect of Pinus Massoniana Bark Proanthocyanidins on Ovarian Cancer Through Induction of Cell Apoptosis and Inhibition of Cell Migration.

Some studies show that in a laboratory setting, they cause cancer cells to self - destruct through a process called apoptosis.

All cells have the ability to go through a process called apoptosis, or programmed cell death.