Sentences with phrase «apoptosis when»

Gadd45b plays a role in cell cycle arrest, and it is a positive mediator in Fas - induced apoptosis when a DNA injury appeared in nonneoplasic cells [28].

Occludin is required for apoptosis when claudin — claudin interactions are disrupted.

Manduca hemocytes also undergo apoptosis when exposed to recombinant Mcf1 [19].

The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of cell suicide known as apoptosis when exposed to agents that induced ER stress.

Not exact matches

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

Chen observed no such growth, however, when she treated retinal explants from normal mice with a compound that blocks apoptosis.

When a cancer cell dies by apoptosis, the result is a neat and tidy process where the dead cell's remains are «recycled,» not contaminating healthy cells around them, and not inducing inflammation.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

«We found that when apoptosis was impaired, for instance by loss of BIM, the BET inhibitors were no longer effective,» he said.

When L - HIPPO was added to virus - infected cells via a carrier called α - CDE, the virus became confined within the cell and the cell would die through natural apoptosis.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

When the team injected the shielded mice with a chemical that blocks cell - to - cell communication before irradiating them, they detected no DNA breaks and the amount of apoptosis decreased more than threefold.

When this machinery detects irreparable damage to the cell, p53 is unleashed to trigger apoptosis.

NF - κB: Inhibition of this gene extends life modestly in a number of lower species, though given its involvement in immunity, inflammation, apoptosis, and other fundamental processes, there is an embarrassment of riches when it comes to trying to explain the roots of the effect.

b. Creating synthetic receptors or signals of cancer, i.e. when cancer related miRNA is activated, you have it also activate a synthetic gene or protein, that is expressed on the membrane surface to activate apoptosis.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

In embryos where the mix of normal and abnormal cells was half and half, the researchers observed that the abnormal cells within the embryo were killed off by «apoptosis», or programmed - cell death, even when placental cells retained abnormalities.

Oncogenes — whose protein products, when activated, cause uncontrolled cell proliferation or prevent cells from undergoing apoptosis.

The TUNEL assay showed more TUNEL - positive cross-sectioned tubules and more spermatogenic cells undergoing apoptosis in IVC male testes when compared to the control mice (Fig. 3).

When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.

It promotes tumor cell proliferation and resistance to apoptosis (programmed cell death after a certain number of cell divisions, a good thing when it comes to cancer cells).

When a healthy cell becomes damaged, it commits suicide and kills itself in a process called apoptosis.

According to a 2011 study from the University of Illinois, when cancer cells were exposed to compounds derived from yerba mate they experience cell death, or apoptosis.

Cancer cells actually shrink when injected with iodine and can experience apoptosis, which means the cancerous cell dies instantly.

In an attempt to «determine the underlying mechanisms for these anticancer effects», cell apoptosis was again to be examined when the blood of a group eating a similar diet was dripped on a cancer cell line.