Sentences with phrase «apoptosis while»

In upcoming investigations, the scientists want to verify their findings on the development of liver cancer and search for active substances that inhibit apoptosis while simultaneously causing the mildest possible side effects.

Not exact matches

While doing her Ph.D., Wang came across a defense mechanism in plants involving apoptosis, where «the plant cell is induced to die around the infection site so the pathogen can not be spread to other tissues,» Wang says.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Activation of ERK1 / 2 triggers G2 checkpoint which is considered protective from radiation - induced cell death [8, 9], while activated AKT is known to promote DNA repair and inhibition of apoptosis induction [10].

While in general terms, a great majority of cancerous tissues decrease their proliferation due to apoptosis caused by radio — and chemotherapeutical regimes, most of them acquire novel mutations bypassing apoptosis to find novel niches to metastasize.

It was initially thought that TNFα - mediated signaling downstream of TNFR1 results in apoptosis, while those downstream of TNFR2 induce proliferation [40].

Read about the monitoring of apoptosis and necrosis in real time using the CLARIOstar's ACU feature, that maintains the appropriate O2 and CO2 environment for cells, while the RealTime - GloTM Annexin V Apoptosis and Necrosis Assay measures cell death using luminescence and fluorescentapoptosis and necrosis in real time using the CLARIOstar's ACU feature, that maintains the appropriate O2 and CO2 environment for cells, while the RealTime - GloTM Annexin V Apoptosis and Necrosis Assay measures cell death using luminescence and fluorescentApoptosis and Necrosis Assay measures cell death using luminescence and fluorescent signals.

Further, C188 - 9 caused a significant rise in apoptosis in the lesions of parous mice, (Figure 6G) while having no detectable effect on proliferation (Figure 6 — figure supplement 3C).

Estradiol promotes the onco (cancer) gene, Bcl - 2, while progesterone promotes the protective gene known as p53 which slows cell apoptosis.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

It effectively blocks cancer cell growth while inducing apoptosis, or cell death, in cancer cells.

While apoptosis would not usually provoke an inflammatory response, special conditions can prove otherwise.

The results showed, «Lauric acid induced apoptosis in Caco - 2 (p < 0.05) and IEC - 6 cells» while butyrate did not.

In a study published this year in Current Drug Targets, a combination of tocotrienols and quercetin induced senescence and promoted apoptosis in many different types of cancer cells, while delaying senescence in healthy cells and rejuvenating formerly healthy senescent cells.

An anti-cancer diet also needs to be low or moderate in complete protein and high - insulemic index foods (to reduce growth promoting IGF - 1), and perhaps low in methionine specifically while high in fiber, phytochemical hormetics (to induce endogenous antioxidant responses and toxin removal), epigenetically active compunds (to reexpress tumor suppressor genes for induce cellular senescence or apoptosis), inflammation inhibitors, and antiangiogenetic compounds.