Sentences with word «apoptotic»
The word "apoptotic" is used to describe a process in living cells known as programmed cell death. It is a natural and controlled way for cells to die, which is important for normal development and maintenance of the body. Full definition
This was consistent with a long - term apoptotic effect of Mcf1 causing widespread cell death and ultimately death of the animal.
journals.plos.org
Furthermore, the drug induced a dose - and time - dependent apoptotic response in chemoresistant melanoma cells via inactivation of Bcl - 2 [21].
They are present in apoptotic bodies of infected cells or can be exposed upon degradation of the microbes within the endocytic pathway.
Dr. Steven R. Goodman, Editor - in - Chief of Experimental Biology and Medicine, said «This study by Huanbiao Mo and colleagues at the Texas Woman's University and UT Southwestern Medical Center demonstrates that geranylgeraniol causes dose dependent apoptotic death of human prostate carcinoma cells.
Annexin V - FITC staining was used as a marker for apoptotic cells, while PI staining was used as an indicator of necrotic cells that had lost membrane integrity.
Bcl - 2 protein expression is topographically restricted in tissue characterized by apoptotic cell death.
Mitochondrial permeabilization releases proteins of varying evolutionary origin, including the ancient apoptosis - inducing factor (AIF) that contributes to caspase - independent apoptosis, metazoan - specific apoptotic protease activating factor 1 (Apaf - 1), and eumetazoan sensu stricto - specific caspase - activated DNase (CAD) and its regulator ICAD.
Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway.
Anti-apoptotic proteins in cancer cells were inhibited, while normal cells» apoptotic programming was left intact.
The mutations in p53 cause failure of apoptotic mechanisms and deregulate cell proliferation, thereby leading to genomic instability and malignant progression.
In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.
The results showed a 70 percent increased apoptotic rate in liver cancer cells compared to normal cells.
Indeed, several key players of the intrinsic apoptotic pathway were differentially regulated in their levels when comparing the epithelial and the mesenchymal subpopulation.
Apoptosis and necrosis were quantified using immunofluorescence assays; bioconjugate - treated cells were early apoptotic after 4 hours, proving effective initiation of programmed cell death.
Moreover, the allospecific apoptotic activity of the putative DN T cells was abolished in two separate experiments using in vitro treatment with anti-Thy 1.2 antibody plus complement, which removed > 97 % of the Thy 1 + cells, as determined by flow cytometry.
Figure 2 (middle line) shows that 50 nmol kahweol induced apoptosis in a small percentage of cells but this effect did not seem to be endothelial cell specific, since only few apoptotic nuclei corresponded to endothelial cells.
However, despite their very low apoptotic rate, the early lesions of I10 mice harbored abundant numbers of cells positive for p53, Bax, and Bak (data not shown), suggesting that as in virgin mice oncogene - activated cells in parous glands are fully capable of activating p53 and its pro-apoptosis targets, but these precancerous cells nevertheless evade apoptosis.
He worked as a graduate student in the Kapahi lab and his research was focused on characterizing apoptotic cell clearance factors in the intestinal tract of fruit flies.
In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated with apoptotic cell death.
Although the molecular events that trigger neuronal death in each of these neurodegenerative diseases is distinct, the downstream apoptotic process through which neurons die in these pathologies are thought to share commonalities to each other, as well as to developmentally - regulated neuronal death.
«Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages»
«We found that in the induced tumors, about half of the T cells were already apoptotic four days after ACT,» says Van den Eynde.
«Flow cytometry identified a large population of apoptotic melanoma cells, and single - cell electrophoresis indicated that mensacarcin causes genetic instability, a hallmark of early apoptosis,» Loesgen said.
«The Vienna team of Dr. Javier Martinez, also a co-corresponding author on the study, could actually show that mutations in CLP1 affect tRNA biogenesis and that CLP1 mutant brain stem cells become more apoptotic (invoking cell death).
This means that Ubx does not control haltere size cell - autonomously by, for example, acting directly on cell cycle or apoptotic checkpoints.
This toxin causes extensive apoptotic cell death in both the midgut epithelium and circulating hemocytes of caterpillar hosts.
Confocal analysis revealed that apoptotic hemocytes are very different in morphology to those exposed to Mcf1 appearing hugely swollen and containing fluorescent puncta having engulfed their dying neighbouring hemocytes (Figure 3E).
The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).
Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions.
Her thesis was entitled «Caspase activation in unidentified apoptotic pathways.»
By providing an exogenous apoptotic gene, which is only transiently expressed in cells that already have the p16 gene active, we can precisely induce the senescent cell to commit suicide.
This model of cancer cell intravasation is better compatible with the release of CTC clusters and apoptotic CTCs and, furthermore, spares the requirement for an elusive and complicated EMT / MET program.
To study the underlying apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.