Caspases are enzymes that play key roles in apoptosis, necrosis and inflammation, and their activation is necessary
for apoptotic cell death.
In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated
with apoptotic cell death.
Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed
by apoptotic cell death.
This research is currently dissecting the proteolytic components of the intracellular pathway that lead to
apoptotic cell death.