Sentences with phrase «apoptotic keratocytes»

His small sculpture «Intrinsic Apoptotic Pathways» (2013) is a cast made from a kapala skullcup.

We were among the first to show that apoptotic bodies could enhance cross priming in patients with spontaneous tumors.

In addition, during puberty and into the third decade, oestrogen has an anabolic effect on the osteoblast and an apoptotic effect on the osteoclast, increasing bone mineral acquisition in axial and appendicular bone.

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin - proteasome systems by phosphatidylinositol 3 kinase

A 70 - 90 % reduction in colony formation has been observed, as well as a remarkable increase in apoptotic cancer cells (cells that are programmed to die).

There are hundreds of other studies that have shown that curcumin turns on natural apoptotic (cell suicide) switches in cancer cells (8).

In the calorie - restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells.

Quercetin is also a «superstar» of chemoprevention because it is one of the rare substances that appears to have an apoptotic effect on the stem cells of certain cancers.

Modulation of age - induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

The results showed a 70 percent increased apoptotic rate in liver cancer cells compared to normal cells.

Anti-apoptotic proteins in cancer cells were inhibited, while normal cells» apoptotic programming was left intact.

Next, we found that the increase of p21Cip1 / WAF1 expression, which occurs upon LA exposure in a p53 - independent manner, is involved in the apoptotic effects prompted by LA in both breast and endometrial cancer cells.

In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated with apoptotic cell death.

These observations demonstrate that with a pregnancy preexisting premalignant mammary cells overcome both the apoptotic response to an oncoprotein and the robust cell death at involution, which normally clears the large mass of cells gained during pregnancy / lactation.

* please note this kit can not be used for the amplification of apoptotic DNA (160 - 170 bp), please see our TruePrime ™ apoptotic cell - free DNA amplification kit.

Mutations in RNAse L that impair the apoptotic response to viral infection were postulated to reflect enhanced susceptibility to infection by XMRV and suggested a potential role for the virus in carcinogenesis [5], [6], [7], [8].

By examining this damage, it was found that the Bax / Bcl2 ratio, a parameter that is indicative of the apoptosis status [21], was increased in the testes of IVC - derived males, suggesting that there were a high number of apoptotic cells in that tissue, and this was confirmed by TUNEL assay.

This research is currently dissecting the proteolytic components of the intracellular pathway that lead to apoptotic cell death.

Notably, genes thought to induce and promote apoptosis through the intrinsic mitochondrial apoptotic pathway, such as KLF10 [32], were not altered in differentiated cells or in treated versus untreated cells.

The TUNEL assay for apoptotic cell detection was performed using the In Situ Cell Death Detection Kit (Boehringer Mannheim GmbH) and was performed according to the manufacturer's instructions.

The number of TUNEL - positive cells in approximately 250 seminiferous tubules of each mouse was counted, and the apoptotic indices were then determined by calculating the ratio of the total number of TUNEL - positive cells / number of counted seminiferous tubules.

In fact, short term treatment of patients with amiodarone leads to a significant decrease in the patient's serum TNFα concentrations while paradoxically the amiodarone toxicity is exerted through TNF - mediated apoptotic pathways [41].

Apoptotic cells are stained green.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

Apoptosis and necrosis were quantified using immunofluorescence assays; bioconjugate - treated cells were early apoptotic after 4 hours, proving effective initiation of programmed cell death.

The extrinsic apoptotic pathway is activated by external signals through transmembrane tumour necrosis factor receptors (TNFRs) whose intracellular death domain interacts with downstream adaptors.

The expression of micro-RNA miR - 663 was induced by mitochondrial reactive oxygen species production, an apoptotic signal and oxidative stress response, and miR - 663 induced the expression of nuclear - encoded mitochondrial respiratory chain subunits.

These off - target effects may actually be beneficial in treating IBD, primary sclerosing cholangitis, primary sclerosing cholangitis / IBD - related CRC, and asthma, whereby a multitude of abnormal signaling involving inflammation, oxidative damage, DNA damage, and apoptotic abnormalities exists to manifest itself into a diseased state.

Figure 2 (middle line) shows that 50 nmol kahweol induced apoptosis in a small percentage of cells but this effect did not seem to be endothelial cell specific, since only few apoptotic nuclei corresponded to endothelial cells.

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.

The mutations in p53 cause failure of apoptotic mechanisms and deregulate cell proliferation, thereby leading to genomic instability and malignant progression.

Arrows point to apoptotic cells.

Symposia X: The Impact of Heat Shock Protein Expression on Muscle Metabolism, Exercise Capacity and Disease Prevention Speakers will present evidence for the functional effects and mechanisms of heat shock proteins and their role in aging, mitochondrial function, apoptotic pathways, insulin sensitivity, myocardial protection and more.

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

(D) Apoptotic cells detected by the TUNEL assay (× 400).

The lab also found that apoptotic tumor cells serve as potent instigators of the T cell immune response and has worked on developing cancer vaccines to mimic PND tumor immunity.

Sciorati C, Monno A, Ascherman DP, Seletti E, Manfredi AA, Rovere - Querini P. Required role of apoptotic myogenic precursors and toll - like receptor stimulation for the establishment of autoimmune myositis in experimental murine models.

Compared with the untreated group and the groups treated with single agents, the number of apoptotic tumor cells was increased following combined treatment (Figure 4D).

For example, by engineering PA - GFP tagged to a mitochondrial matrix protein (mito - PAGFP) the Youle Lab was able to visualize and quantify the fusion dynamics of mitochondria in healthy and apoptotic cells (9).

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

To study the underlying apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.

More recently, his research has focused on molecular mechanisms that establish the apoptotic program in response to protein misfolding in the ER, studies that have shed light on the mechanism by which cancer cells survive in a stressful environment.

By providing an exogenous apoptotic gene, which is only transiently expressed in cells that already have the p16 gene active, we can precisely induce the senescent cell to commit suicide.

Lin chart illustrates the correlation between Cyclin D1 IOD in Grade III with percentage of apoptotic phase.

Inhibition of Rac GTPase triggers a c - Jun - and Bim - dependent mitochondrial apoptotic cascade in cerebellar granule neurons.

The supernatant of apoptotic cells causes transcriptional activation of hypoxia - inducible factor — 1α in macrophages via sphingosine -1-phosphate and transforming growth factor - β.

Her thesis was entitled «Caspase activation in unidentified apoptotic pathways.»

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.