The mutations in p53 cause failure of
apoptotic mechanisms and deregulate cell proliferation, thereby leading to genomic instability and malignant progression.
To study the underlying
apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.
Not exact matches
TNF - α Inhibits Macrophage Clearance of
Apoptotic Cells via Cytosolic Phospholipase A2 and Oxidant - Dependent
Mechanisms.
More recently, his research has focused on molecular
mechanisms that establish the
apoptotic program in response to protein misfolding in the ER, studies that have shed light on the
mechanism by which cancer cells survive in a stressful environment.
Symposia X: The Impact of Heat Shock Protein Expression on Muscle Metabolism, Exercise Capacity and Disease Prevention Speakers will present evidence for the functional effects and
mechanisms of heat shock proteins and their role in aging, mitochondrial function,
apoptotic pathways, insulin sensitivity, myocardial protection and more.