Sentences with phrase «appropriate animal model»

Although experimental and clinical evidence suggest that endogenous sex hormones influence bone sarcoma genesis, the hypothesis has not been adequately tested in an appropriate animal model.

Dr. Jay Nelson stated the first hurdle in testing possible vaccine candidates is determining an appropriate animal model for the Zika virus.

Using a new technique to deliver gene - therapy - like intervention directly where it's needed, researchers at Thomas Jefferson University successfully increased or decreased the muscle tone of the anal sphincter in appropriate animal models.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

It's extremely important to choose the appropriate animal models, and veterinarians have the training to do that.»

«But really, there is an opportunity with appropriate animal models to make a huge difference for the human community as well.»

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

The general approach is to develop new vector systems and delivery methods, test them in the appropriate animal models, uncover the mechanisms involved in vector transduction, and use the most promising approaches in clinical trials.

Appropriate animal models and translational research to study sex differences are needed to get more insight into the pathophysiology and complex interplay of hormones, genes, lifestyle, and environment.

One of the limitations of preclinical efficacy evaluation is the lack of appropriate animal models covering important aspects of the human disease.

Not exact matches

«The key to establishing a standardized melamine - induced animal bladder stone (cystolith) model,» the paper's abstract begins, «is to determine the most appropriate daily dose of dietary melamine, which is unknown.»

Specifically, the IOM committee says NIH should support only biomedical research with chimpanzees if it promises to advance public health, can not be done with another research model or ethically performed with humans, and the animals are kept in ecologically appropriate housing or habitats.

Research will aim to improve the predictive value of animal models for vaccine evaluation, provide consultancy on the selection of appropriate models, and develop innovative approaches to characterise in vivo antigen behaviour and host responses whilst reducing animal use.

The identification of effective compounds in vitro allows, after verification in animal models appropriate to consider the establishment of a clinical trial.

The idea behind TPC is to take in as many animals as possible to train, socialize, and to use this teaching humane society model to role play appropriate reactions and interactions to the pet as a whole.

Safety and Security: Notifies Shelter Manager and co-workers of observations of health or behavioral changes Promptly contacts appropriate individuals about any animals in distress Monitors building and equipment safety and notifies Shelter Manager of needed repairs or dangers Models and encourages safe practices and follows protocols and regulatory compliance throughout the organization

Provide your child with multisensory experiences involving animals: stories, movies, art work, coloring pages, modeling appropriate behavior with animals using stuffed animals to help kids practice, and real - life interactions.