Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of
archaeal membrane lipids.
Not exact matches
Excitingly, these proteins are functionally enriched for
membrane bending, vesicular biogenesis, and trafficking activities, suggesting that eukaryotes evolved from an
archaeal host that contained some key components that governed the emergence of eukaryotic cellular complexity after endosymbiosis.
This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these
archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and
membrane deformation.
Recently, this very lab described the Asgard Archaea, an
archaeal phylum with clear signs of cellular complexity, such as the presence of eukaryotic
membrane trafficking components.