Our aim is to shed light on the evolutionary path by which
archaeal proteins gave rise to the eukaryotic cytoskeleton.
I am currently using fission yeast as a system to express and image
Archaeal proteins.
To gain a better understanding of the evolutionary path by which
these archaeal proteins gave rise to the eukaryotic cytoskeleton we have assembled a team of global experts in cytoskeletal biology and evolutionary cell biology.
Not exact matches
Excitingly, these
proteins are functionally enriched for membrane bending, vesicular biogenesis, and trafficking activities, suggesting that eukaryotes evolved from an
archaeal host that contained some key components that governed the emergence of eukaryotic cellular complexity after endosymbiosis.
Comparison of
archaeal and bacterial genomes: computer analysis of
protein sequences predicts novel functions and suggests a chimeric origin for the archaea.
This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these
archaeal lineages, including genes encoding
proteins such as actin, tubulin, and several
proteins involved in transcription and membrane deformation.