Limitations of sequencing technologies kept
archaic human DNA largely out of reach until 2006.
Not exact matches
«This scenario reconciles the discrepancy in the nuclear
DNA and mitochondrial
DNA phylogenies of
archaic hominins and the inconsistency of the modern
human - Neanderthal population split time estimated from nuclear DNA and mitochondrial DNA,» says researcher Johannes Krause, also of the Max Planck Institute for the Science of Human His
human - Neanderthal population split time estimated from nuclear
DNA and mitochondrial
DNA,» says researcher Johannes Krause, also of the Max Planck Institute for the Science of
Human His
Human History.
Other geneticists at the meeting zeroed in on
archaic DNA «deserts,» where living
humans have inherited no
DNA from Neandertals or other
archaic humans.
That in turn could help determine when
humans interbred with
archaic hominids on other continents — such as Neandertals in Europe and Denisovans in Asia — whose genes linger in the
DNA of some modern people (SN: 6/13/15, p. 11).
Today, almost all
humans outside Africa carry traces of
archaic DNA.
The researchers were searching for
archaic DNA sequences in those
human genomes at frequencies much higher than would be expected if those genes weren't doing people any good.
And now that investigators can sequence entire ancient populations, ancient
DNA is revealing that
humans on every continent are a complex mix of
archaic and modern
DNA.
By sequencing ancient
DNA from the fossils of
human ancestors, researchers have recently discovered new types of ancient
humans and revealed interbreeding between our ancestors and our
archaic cousins, including Neandertals.
«There are signs that intermixing with
archaic humans was occurring in Africa, but given the warmer climate no one has yet found African
archaic human fossils with sufficient
DNA for sequencing.»
The
DNA data suggest not one but at least two instances of interbreeding between
archaic and modern
humans, raising the question of whether Homo sapiens at that point was a distinct species (see sidebar).
New
DNA data from
archaic human species are providing a much higher resolution view of our past.
But ancient -
DNA sequencing is beginning to shed some light on the issue.11 For example, by comparing a
human HAR sequence with the HAR sequence of an
archaic hominin, researchers can estimate if the HAR mutated before, after, or during the time period of our common ancestor.12 This approach has revealed that the rate at which HAR mutations emerged was slightly higher before we split from Neanderthals and Denisovans.3, 13 As a result, most HAR mutations are millions of years old and shared with these extinct hominins (but not with chimpanzees).
Feb. 11, 2016 — The first study that directly compares Neanderthal
DNA in the genomes of a significant population of adults of European ancestry with their clinical records confirms that this
archaic genetic legacy has a subtle but significant impact on modern
human biology.