They compared the animals» ability to negotiate a radial -
arm water maze, a standard test of cognitive ability, with that of regular J20 mice and of normal mice at 4, 9, and 14 months of age.
They have spatial learning and memory defects as assessed in the Morris
water maze and the radial
arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior.