I am trying to disentangle hormone / hormone receptor effects, this bit is made as simple as possible; Test - > E2 (
Aromatase) Test - > DHT (5α - reductase) DHT - > 3,17 diol (three known enzymes) E2 is a agonist to ERa, ERb1 to Erb5; Tissue specific distribution.
Then a special protein found in muscle and fat cells throughout your body makes an enzyme called
aromatase, which changes androgen into estrogen.
Because breast tissue has
aromatase activity,30 - 33 testosterone may serve as a substrate for local estradiol formation in the breast.
In lab studies, naringenin inhibits enzymes that activate carcinogens and
the aromatase enzyme that stimulates estrogen production.
DIM is also
an aromatase inhibitor which blocks the enzyme aromatase from turning androgens into estrogens.
Nicotine may also act as an anti-estrogenic compound, inhibiting
aromatase and one of the two estrogen receptors directly; this may underlie some of the side - effects associated with chronic usage of nicotine / cigarettes, particularly in women.
As
aromatase inhibition is dose - dependent, it has been suggested that
aromatase is less suppressed in the testes than in adipose and muscle tissue, which explains the incomplete effectiveness of
aromatase inhibition in men.
Another problem with the idea of eating a calorie surplus in order to boost testosterone is the fact that you'd slowly get fat, which would increase
your aromatase enzyme activity, and therefore boost the conversion from testosterone to estrogen.
The compounds in green tea can inhibit
aromatase too, which is an enzyme that turns androgens (male hormones like testosterone) into estrogen.
As a result, people with more fat cells in their bodies, have high levels of
aromatase and higher levels of estrogen.
Part of the mechanism is by androgenic interference with the estrogen receptor (ER) and lowering circulating estrogen levels by competitively inhibiting
the aromatase enzyme.
The reason: By blocking the 5 - alpha reductase enzyme they're actually giving free rein to another substance called
aromatase — an enzyme in your body that, when left alone, wreaks absolute havoc in your body by converting testosterone into estradiol — the most powerful form of estrogen!
They can help decrease the activity of
aromatase and therefore lower the production of estrogen in men.
For men,
their aromatase levels will decrease, and naturally their estrogen levels will decrease and their testosterone levels will increase.
The aromatase enzyme is involved in the production of oestrogen, the female hormone that blocks testosterone production.
When we gain more fat cells, we will have higher levels of
aromatase.
Phytonutrients have also been found to lower
aromatase in your body and therefore improve a man's testosterone levels naturally.
Letrozole, also commonly referred to as an oral
aromatase inhibitor that is usually used in treating hormonally responsive breast cancer after undergoing surgery.
Kale contains indole -3-carbinol, a phytochemical that reduces the activity of
the aromatase enzyme in the body.
Both men and women have an enzyme, called
aromatase, in their fat cells.
Chrysin - may limit the activity of
aromatase, resulting in lower estrogen levels and increased testosterone levels.
Flavonoids such as chrysin are of considerable interest because they suppress excess estrogen via
their aromatase - inhibiting properties.
Estrogen production in endometriosis and use of
aromatase inhibitors to treat endometriosis
The scientists conducting the study concluded by stating that
the aromatase - inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant - based diets.
A bioflavonoid known as chrysin has shown great potential as a natural
aromatase - inhibitor when it was first isolated.
While this cancer preventing effect is most important for women, inhibiting
aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state.
Two recent studies have identified specific mechanisms by which chrysin inhibits
aromatase in human cells.
In small amounts, DIM can both inhibit
the aromatase enzyme (and prevent conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body.DIM also exerts numerous anti-carcinogenic (anti-cancer) effects in the body and is one of the reasons this vegetable family is seen as healthy.
Estrogen is converted from testosterone via a process known as
aromatase.
In a study published in the Journal of Steroid Biochemical Molecular Biology (1993; Vol 46, No 3), chrysin and 10 other flavonoids were compared to
an aromatase - inhibiting drug (aminoglutethimide).
And
aromatase is the first enemy of testosterone.
The study tested
the aromatase - inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures.
AE3 contains 500 mg of pure chrysin extract, combined with Bioperin to enhance bio-availability, to safely and effectively inhibit
aromatase.
The enzyme
aromatase is produced in belly fat and has the primary function of seeking out testosterone to convert to estradiol.
Indirectly through
the aromatase conversion of testosterone into estrogen, it reduces bone density.
In many in vitro (artificial environment) studies, chrysin has been shown to be a very potent and natural inhibitor of human estrogen
aromatase.
For example, what if spearmint tea works by increasing
the aromatase enzyme, the enzyme which creates estrogen via conversion from testosterone, and thus increases overall estrogen levels too?
Fat tissues contain an enzyme called «
aromatase,» which changes androgen hormones, and which is produced in the adrenal glands.
It also contains
aromatase inhibitors such as chrysin which prevents the conversion of testosterone to estradiol.
Chrysin - Chrysin (5,7 - Dihydroxyflavone) is promoted in bodybuilding to be an effective inhibitor of an enzyme known as
aromatase which causes the conversion of testosterone into estradiol and androstenedione into estrone.
With clients, we most often correct
this aromatase issue with the use of two safe, natural, and extremely powerful aromatase - inhibitors.
Although supplements purported to increase testosterone have been around for awhile, recently we have seen the introduction of novel new nutrients which are research proven to increase testosterone levels such as various forms of
aromatase inhibitors such as pZole seen in the supplement Triazole, which reduces estrogen and causes a rise in testosterone, as well as D - Aspartic Acid (Testforce 2) and those based around the Prolensis herb (Tropinol).
Menopausal women continue to produce larger amounts of estrogen through
aromatase, even when their ovaries produce little.
I have had so many people comment on how strong and full my hair looks, and this at a time when I was extremely worried about hair thinking and potential hair loss as a result of starting on a five year programme of
aromatase inhibitors.
Aromatase is an enzyme found largely in your fat cells that converts androgens, like testosterone, into estrogen.
Grape Seed Extract (95 % Proanthocyanidin)(150 mg): Proanthocyanidin helps block the conversion from testosterone to estrogen via inhibiting
the aromatase enzyme and also promotes nitric oxide production.
That's why the incidence of breast cancer is going up in men when they're exposed to certain estrogenic chemicals on the job, but also there can be epigenetic changes of
the aromatase genes that make you more prone to not being able to do a good job of rinsing your hormones especially estrogen out of your breast.
This is because as bodyfat goes up so do levels of
the aromatase enzyme and this means that the rate at which men start producing estrogen goes up.
What all of this means is that peony may be helpful in regulating menstrual cycles, as it supports healthy follicle (egg) development in the ovaries via
the Aromatase enzyme.
Low testosterone may be due to inadequate production or signaling from any gland, increased conversion to estrogen (due to
aromatase enzyme), or increased amount of sex hormone binding globulin (SHBG), which binds up too much estrogen or testosterone.