Sentences with phrase «aromatic rings»

The common denominator of the three drugs discussed here is their direct interaction with DNA in accordance with their extended molecular structures containing aromatic rings.

Thus, the arrangement of benzene rings found in RIPK2 inhibitor 1 resembles the geometry of the corresponding aromatic rings in ponatinib bound to RIPK2.

Almost 90 percent of known active pharmaceutical ingredients contain one or more «heterocyclic aromatic rings», structures that contain atoms of at least two different elements.

It also is the first 6 - atom aromatic ring (a hexagonal array of carbon atoms bristling with hydrogen atoms) molecule ever detected with a radio telescope.

The switch is derived from a compound classified as a hemithioindigo, in which a so - called thioindigo moiety is linked via a carbon double bond (C = C) and a single bond (C - C) to a planar aromatic ring.

While aromatic rings are commonplace in molecules seen here on Earth (they are found in everything from food to medicine), this is the first such ring molecule ever seen in space with radio astronomy.

«As a result of screening about 200 compounds, we found that (3 - furyl) diphenylmethane (chem7), which is a triarylmethane that contains 2 phenyl groups and a furyl (a 5 - membered aromatic ring containing 4 carbons and an oxygen atom in the ring) group, had strong inhibitory activity on plant cell division,» says Ueda.

Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.

SAR studies indicated that the central aromatic ring is crucial for high CXCR4 affinity, and that a one - carbon separation between the central aromatic phenyl ring and the nitrogen of the acyclic linker is strictly required for potency.

Blue boxes are signals due to three - bond J - coupling between aromatic ring protons.

«These pi - pi aromatic interactions play a very, very important role in this specific polymer and in any polymer that contains aromatic rings,» Lyulin said.

Dunlap says the coral byproduct is chemically simpler than the aromatic ring molecules at the basis of commercial sunscreens and thus is less likely to trigger allergic responses.

The Friedel — Crafts reaction (1), named after its respective French and American pioneers, has long been used to attach alkyl groups to aromatic rings.

This derivative reacts to light by altering the orientation of the aromatic ring in different ways depending on the nature of the medium in which it finds itself.

We carried out the reaction in water at room temperature and obtained a highly reactive intermediate aryne (an aromatic ring with a triple bond), resulting in novel phenolic substances to be further obtained.

Triarylmethanes are a group of compounds that derive from methane (a molecule consisting of carbon with 4 hydrogen atoms attached to it) and consist of a carbon atom center with 3 aryl (aromatic ring) groups and a hydrogen atom.

Previous SAR studies on pentapeptides showed that at least three functional groups on the peptide side - chains are required: an aromatic ring (such as 2 - naphthyl - or 3 - indolyl group), one or two guanidino groups, and a phenol group.

The lack of ROEs between HN22 and either HC17 or HC25 indicates that the central methyl - containing aromatic ring is roughly perpendicular to the amide plane of HN22, as would be expected based on steric considerations.

Aromatic amino acids (AAA) are amino acids that include an aromatic ring, such as six - carbon benzene (C6H6) or some other similar ring structure.

It is different from T3 or Triiodothyronine in terms of the attachment of the atoms to the aromatic rings.

We find that regioselectivity of electrophilic attacks is determined by the Hirshfeld charge distribution on the aromatic ring.