Sentences with word «artesunate»

But in 2005, a large study in four Asian countries, led by Dondorp and Nicholas White, both employed by the University of Oxford in the United Kingdom but based at Mahidol University in Bangkok, showed that injections of artesunate reduced deaths from severe malaria by 35 % over quinine.

Surprisingly, the mutant parasites can not be killed by the anti-malarial drug chloroquine, which interferes with hemozoin formation, but yet, remain sensitive to the drug artesunate which targets another pathway of hemoglobin digestion.

Since then, several Asian countries have started replacing quinine with artesunate for severe malaria.

Dondorp's study showed that compared with an older drug called quinine, a new one called artesunate reduces the risk of death from severe malaria in African children by 23 % — a finding that could save tens or even hundreds of thousands of lives annually.

In a paper published in last week's issue of The New England Journal of Medicine, for instance, Noedl — who is now at the Medical University of Vienna — reports that out of 60 patients from western Cambodia treated with artesunate, two had delayed parasite clearance, with times of 133 and 95 hours, compared with the average of 59 hours.

These findings informed new WHO guidelines reinstating artesunate plus mefloquine as the first - line ACT in Cambodia where dihydroartemisinin - piperaquine treatment has failed.

And on the Thailand - Myanmar border, using artesunate plus mefloquine stemmed the high rate of malaria infections and restored mefloquine to its previous efficacy.

In one southern village, artesunate treatments lowered the proportion of residents with blood parasites from 42 to 4 percent in just five years.

Consider that malaria affects more than 500 million people worldwide, and yet this past summer the Financial Times reported that French drugmaker Sanofi - Aventis faced half the demand it had expected for its anti-malaria compound artesunate.

As soon as possible, WHO should recommend artesunate for severely ill children, because that will stimulate African countries to switch policies, says Olugbenga Mokuolu, a clinical researcher at the University of Ilorin Teaching Hospital in Nigeria who collaborated on the study.

If all African children with severe malaria received artesunate in time, between 100,000 and 200,000 lives could be saved annually, he says.

The difference between the drugs might be that, as opposed to quinine, artesunate also kills very young malaria parasites, Dondorp says.

(2) Compared to ingesting Artesunate or Quinine, the new DDS increased treatment efficiency by 20 and 240 times respectively in animal experiments.

After years on the shelf, mefloquine is effective again in Cambodia, and WHO has recommended that the country switch to a combination of artesunate and mefloquine.

To test their theory, they created a new DDS by combining the antimalarial drugs Artesunate and Quinine with MCT - 41 and performed in vitro and in vivo experiments.

More than 2 years after WHO recommended Cambodia switch from DHA - PPQ to an artesunate - mefloquine combination, the drugs are just arriving.

The researchers showed that they could load two malaria drugs, artesunate and piperaquine, into these polymers.

Additional study findings suggest that artesunate, a form of artemisinin, plus mefloquine, a different long - acting partner drug, should be the first - line ACT in areas where dihydroartemisinin - piperaquine treatment has failed, the study authors note.

But their most potent weapon was artesunate.

Artemisinin's water - soluble derivative, artesunate, appeared to be more promising.

«Dihydroartemisinin - piperaquine is more effective than artemether - lumefantrine, and has fewer side effects than artesunate - mefloquine» concludes a systematic review published by the Cochrane Infectious Disease Group, hosted by LSTM.

The team of authors from South Africa, Kenya, Geneva and Liverpool included 27 randomized studies, enrolling 16,382 adults and children, which directly compared the relative efficacy and safety of dihydroartemisinin - piperaquine and the widely used alternatives; artemether - lumefantrine, artesunate plus mefloquine, and artesunate plus amodiaquine.

Areas of mass drug administrations (MDA) of artesunate / amodiaquine malaria chemoprevention (ASAQ - CP) during the Ebola outbreak, Monrovia, Liberia, 2014.

They also demonstrated that it has a direct role in drug action and susceptibility to artesunate, an important member of the artemisinin drug family.

«Through this multi-year collaborative effort, we now have an improved understanding of the protective molecular mechanisms of the malaria parasite and its drug susceptibility to artesunate.

Of the children who received quinine, 10.9 % died; in the artesunate group, 8.5 % died.

Artesunate is slightly more expensive, but its administration is cheaper, and an as - yet - unpublished cost - effectiveness study by Dondorp and colleagues shows that the average cost per life saved using the new drug is only $ 123.

(Artesunate is part of a drug family derived from Artemisia annua, a plant that has long been used in Chinese medicine.)

Given the results of this and previous studies, artesunate should replace quinine as soon as possible worldwide, she says.

Artesunate, produced by a Chinese company called Guilin Pharmaceutical, is easier to give than quinine, which must be administered very slowly and carefully to avoid a dangerous drop in blood pressure.

Antibiotics, Ampligen, Interferons, Nexavir, Valcyte, Valtrex, Vistide, Artesunate, etc. all are open game here.