Sentences with phrase «as abl»

Known as Abl, it is one of a family of enzymes that usually help guide normal cell growth, but a mutation of it drives white blood cells to divide incessantly.

Its regional brands — such as ABL Management, Aladdin, A'viands, Cura, STARR Catering and Valley Services — have operational autonomy in their local regions and markets and receive overall corporate support for finance, purchasing, sales and marketing and human resources.

Not exact matches

For companies with a strong credit rating and advanced, verifiable financial reporting (such as receivable and payable summaries), Liquid Capital's Asset - Based Lending (ABL) solution provides an excellent financing option that is more cost - effective, creative and discreet than anything else in the marketplace.

Businesses that are acquiring commercial real estate may have additional financing needs such as working capital, equipment needs or some form of asset - based lending (ABL).

The first out ABL lenders sought full payment for contingent indemnification claims and certain expenses as a condition to a credit bid by Standard General, its counterparty under the 2013 credit agreement AAL.

First, the first out ABL lenders under the 2013 credit agreement objected by claiming that under their applicable AAL, Standard General as last out lender under that facility was precluded from submitting a credit bid if any obligations to the first out ABL lenders remained outstanding.

«Banks are mindful of the amount and magnitude of transactions consummated in the ABL market that are characterized as special mention credits and / or leveraged loans,» stresses Feinberg.

This year Bunning and rookie congressman Tom McMillen, the Maryland Democrat who played 11 years in the NBA, (page 70) joined representatives Jack Kemp (Buffalo Bills) and Mo Udall (the old ABL Denver Nuggets) and Senator Bill Bradley (New York Knicks) in the Jock Caucus, as Udall has come to call the collective of five former pro athletes now serving in Congress.

And it was unbelievable how fortunate these moms felt, who were not able to produce as much, that they were able to get donor milk; and how incredibly fortunate they felt that their babies were able to receive breast milk when they thought that they may not be abl to, so that's amazing that you were on that list!

According to the Chief Executive Officer of ABL, Ugo Udezue, «this is the first of its kind in the history of private sports in Africa, our goal is to provide a safe and socially conducive entertaining environment with basketball as the epicenter».

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

ABL Co reported to Tokyo Energy & Systems Inc, which in Fukushima manages some 200 workers as a first - tier contractor under Tepco.

We review progress with the receptor tyrosine kinases (growth factor receptors EGFR, VEGFR, and FGFR) and nonreceptor tyrosine kinases (Bcr - Abl), where advances have been made with cancer therapeutic agents such as Herceptin and Gleevec.

The resulting thermoplastic — called ABL for acrylonitrile, butadiene, lignin — is recyclable, as it can be melted three times and still perform well.

Consequently, bcr - abl is referred to as p210 or p185.

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

TRAIL - enhanced apoptosis as measured by cleavage of caspase - 3 (Fig. 4I), and knockdown of ABL kinases increased the sensitivity of 1833 breast cancer cells to the proapoptotic effects of TRAIL (Fig. 4, G to I).

Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which encodes a receptor tyrosine kinase), IL6 (which encodes interleukin - 6), MMP1 (which encodes matrix metalloproteinase 1), and TNC (which encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.

Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J).

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

This rules out the possibility that resistance to inhibitors results from a steric hindrance as proposed for the Thr315 mutations of ABL.13, 33 However, the crystal structures of JAK1 and JAK2 also show that Phe958 or Tyr931, respectively, are in direct contact with the CMP6 inhibitor.21 The replacement of Phe958 by Val / Cys / Ser / Leu abolishes this interaction and should decrease the affinity for this compound (Figure 2C).

In addition to RIPK2 binding as part of this computer - based (initial) screening, we selected compounds that inhibited epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously identified RIPK2 inhibitors.

This discovery led him to evaluate second generation Abl kinase inhibitors, such as the dual Src / Abl inhibitor dasatinib, which received fast - track approval at the FDA in June 2006.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

Moderate - to - severe periodontal disease was defined as cumulative numbers of teeth ever exhibiting PD ≥ 4 mm or ABL ≥ 40 %.

About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.

Developed through a collaborative process that involved public school leaders from Tennessee, Texas, California, and Pennsylvania as design partners, the Abl platform enables administrators to transform an otherwise static process into a flexible approach that allows principals to test and evaluate scheduling scenarios.

«The master schedule is, in many ways, the blueprint of a school — but a Rubik's Cube of programs, people, and events can make the scheduling process overwhelming and time - consuming for school leaders,» said Abl Founder and CEO Adam Pisoni, who previously served as CTO and Co-Founder of Yammer.

WHEELS: 19» 5 - TRIPLE SPOKE TECH MATTE BLACK - inc: Diamond cut, Tires: P255 / 40R19 AS, MOMENTUM PLUS PACKAGE - inc: 4 - Zone Electric Climate Control, Cooled Glovebox, 12.3» Driver Display (Digital Instrument Cluster), Headlight High Pressure Cleaning, Active Bending Lights (ABL), Thor's Hammer daytime running lights (DRL) and auto highbeam (AHB), HEATED FRONT SEATS & HEATED STEERING WHEEL - inc: Heated Steering Wheel, Heated Front Seats.

An Introduction to Asset Based Lending (ABL) Asset Based Lending is a financing method that uses the short term assets of a business as the basis of the loan facility.

Both the caravans and the camp site have electricity hookups as well as a comfortable abl...

In an attempt to regenerate awareness towards the island of Bali, ABL has recently created a web - log (commonly known as blog)-- http://blog.baliwww.com The main function of this web - log is that it can be viewed daily...

About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.

MELBOURNE — 22 January 2015 — Aderant, the world's largest independent legal software company, announced today that one of Australia's premier law firms, Arnold Bloch Leibler (ABL), selected Aderant Expert as its new practice management system following a thorough review of the market and a detailed evaluation process.

About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.

I offer Qualified key skills as follows: Good Communicator Decision Maker Abl...

About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.

As a hard money lender specializing in fix and flip loans, ABL's primary focus is providing fast and reliable access to capital for our investors.

At ABL, we have closed loans in as little as 48 hours, and have an average close time of 10 days, unlike a conventional loan which takes a minimum of 60 days to close.

Historically, ABLs have been seen as a solution for industries with higher levels of accounts receivable and inventory, such as durable goods manufacturers, wholesalers, consumer product companies, rental companies / equipment leasing, energy companies and retailers.