Sentences with phrase «as cerebellar»

The mutation causing cerebellar degeneration (also known as cerebellar abiotrophy, cerebellar ataxia, cerebellar cortical degeneration, CA) has been identified in the laboratory of Dr. Natasha Olby at North Carolina State University.

She has a condition known as Cerebellar Hypoplasia.

Vaccination, at least with a live vaccine, should be avoided during pregnancy as cerebellar hypoplasia (see above) can result in the kittens.

Because there are no exclusive tests to diagnose cerebellar abiotrophy, the veterinarian will most likely perform various tests to rule out other conditions that have similar symptoms such as cerebellar hypoplasia and other central nervous system disorders.

Not exact matches

However, cerebellar stimulation is still an experimental approach and is not FDA approved as a therapy.

In humans, the cerebellum's extensive connectivity with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autism.

In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD - like features.

She added that, «attempts to generate the cerebellum from human iPS cells have already met with some success, and these patient - derived cerebellar neurons and tissues will be useful for modeling cerebellar diseases such as spinocerebellar ataxia.»

Because the study used cognitive stress as a challenge, it was not confounded by potential group differences in stimulant - induced changes in cerebellar radiotracer delivery.

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

Primary neonatal cerebellar neurons have been used as a suitable model to evaluate developmental neurotoxicity because they allow for the observation of the various stages of neurodevelopment, including proliferation, migration, differentiation, and morphological and functional maturation [18].

Abbreviations: AMPAR, AMPA receptor; AS, Angelman syndrome; BDNF, brain - derived neurotrophic factor; CaMKII, α - calcium / calmodulin - dependent protein kinase II; CGN, cerebellar granule neuron; co-IP, coimmunoprecipitation; DG, dentate gyrus; ERK, extracellular signal - regulated kinase; fEPSP, field excitatory postsynaptic potential; Gab1, Grb2 - associated binder 1; HFS, high frequency stimulation; IGF, insulin - like growth factor; LTP, long - term potentiation; PSD - 95, postsynaptic density protein - 95; SYN, synaptophysin; WT, wild type

Wheat can also inflict direct damage on the brain and nervous system and show up as a condition called cerebellar ataxia, the progressive loss of balance and bladder control, and peripheral neuropathy, the loss of feeling, usually in the feet and legs.

A cat with cerebellar hypoplasia will need to be protected when out of the house, as my healthy cat is here.

Watching an affected cat as it tries to move is very sad for someone who isn't familiar with cerebellar hypoplasia, but the condition doesn't get any worse once a kitten is born and isn't painful.

The cause of cerebellar abiotrophy is not known, but it is presumed to be congenital in certain breeds such as:

Those dogs with cerebellar abiotrophy usually show symptoms of exaggerated movements leg movements and goose stepping (overshooting or undershooting the intended step) as well as the lack of menace (blink) response.

The Cavalier King Charles Spaniel is a breed well - known to have a birth defect in the occipital bone leading to cerebellar herniation, a condition known as Syringomyelia.

LSD - Affected dogs show clinical symptoms of progressive cerebellar ataxia, sometimes accompanied by episodic nystagmus (abnormal eye movements), clumsiness and behavioral changes, such as restlessness, depression and aggression towards people or other dogs.

Hip dysplasia can be a concern with this dog, as can cerebellar ataxia.

We can describe magnetic resonans imaging findings as a narrow subarachnoid space in cervicomedullar junction, occipital bone compression on caudal cerebellum, rostral movement of caudal cerebellum, syringomyelia, cerebellar herniation from foramen magnum and kinked appearance of caudal medulla.

The underlying cause of this disease, the genetic basis of this disease as well as defining an appropriate approach to decreasing the incidence of this disease, commonly called Cerebellar Degeneration or Cerebellar Abiotrophy (CA), is ongoing at a number of centers.

Like tumors, cerebellar degeneration is difficult to detect without a diagnostic such as an MRI.

Routine blood work to rule out a systemic problem and assess the anesthetic risk better able to identify fluid build up, swelling, cysts, bleeding ad other subtle soft tissue changes inside the brain and therefore an MRI is a better able to identify fluid build up, swelling, cysts, bleeding ad other subtle soft tissue changes inside the brain and therefore an MRI is a better tool, especially if the dog has signs of brainstem or cerebellar disease, or if it is a breed of dog that is predisposed to gliomas, such as the Boston terrier.

We have included content that will serve owners, breeders and veterinarians as well; informational and in depth descriptions of the conditions that affect the mainly small breed dogs that exhibit characteristic symptoms and signs of cerebral / cerebellar compression and impaired CSF flow.

In contrast to pure cerebellar disease, a persistent fine tremor at rest is usually present as well as a marked intention tremor.

Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by cerebellar parenchyma (Rostral Cerebellar CCF Percentage and Caudal Cerebellar CCF Pecerebellar parenchyma (Rostral Cerebellar CCF Percentage and Caudal Cerebellar CCF PeCerebellar CCF Percentage and Caudal Cerebellar CCF PeCerebellar CCF Percentage).

In order to assess the clinical significance of cerebellar volume and CCF volume as prognostic indicators, further cohort and longitudinal studies are needed.

These parameters are accepted standards in canine brain volume measurement as they have been used in a study of cerebellar atrophy [22] and CCF parenchyma volume [18], [19].

Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by cerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF Pecerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF PeCerebellar CCF Percentage, panel B: Caudal Cerebellar CCF PeCerebellar CCF Percentage).

Dandy Walker - Like Malformation (DWLM) is a form of cerebellar ataxia which is inherited as an autosomal recessive trait.

Dogs with round cerebellum shape and no evidence of narrowing or obstruction of the CSF channels were defined as unaffected, dogs with indentation of the cerebellum by the supraoccipital bone and a narrowed but not obstructed CSF channel (signal consistent with CSF between the caudal vermis and the foramen magnum) were defined as mild CM and dogs where the cerebellar vermis is impacted into or herniated through the foramen magnum were defined as affected.

The volume of the cerebellum is expressed as a percentage of the total brain volume (Cerebellar Brain Percentage).

The volume of the cerebellum is expressed as a percentage of the caudal cranial fossa volume (Panels A and B: Cerebellar CCF Percentage) and a percentage of the total brain volume (Panels C and D: Cerebellar Brain Percentage).

Cerebellar crowding in the rostral and caudal parts of the CCF was expressed as the percentage of that part of the CCF which was occupied by cerebellum (Caudal Cerebellar CCF Percentage and Rostral Cerebellar CCF Percentage).

Relative cerebellar volume was defined as the volume of the cerebellum divided by the total volume of brain parenchyma.

Unlike humans, we found that CKCS do not appear to have age - related atrophy as there was no correlation between relative cerebellar volume and age.